CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear RNA export factor 1 
Protein Synonyms/Alias
 Protein small bristles; DmNXF1; Protein tip-associating 
Gene Name
 sbr 
Gene Synonyms/Alias
 nxf1; CG1664 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
51NKRRVSFKPSQCLHNacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm. 
Sequence Annotation
 DOMAIN 113 193 RRM.
 REPEAT 255 280 LRR 1.
 REPEAT 281 304 LRR 2.
 REPEAT 305 332 LRR 3.
 REPEAT 333 360 LRR 4.
 DOMAIN 375 529 NTF2.
 DOMAIN 618 672 TAP-C.
 MOD_RES 561 561 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Leucine-rich repeat; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 672 AA 
Protein Sequence
MPKRGGGSSQ RYNNNVGNGG GRYNAPEDFD DFDVEDRQRR KDRNKRRVSF KPSQCLHNKK 60
DIKLRPEDLR RWDEDDDMSD MTTAVKDRPT SRRRGSPIPR GKFGKLMPNS FGWYQVTLQN 120
AQIYEKETLL SALLAAMSPH VFIPQYWRVE RNCVIFFTDD YEAAERIQHL GKNGHLPDGY 180
RLMPRVRSGI PLVAIDDAFK EKMKVTMAKR YNIQTKALDL SRFHADPDLK QVFCPLFRQN 240
VMGAAIDIMC DNIPDLEALN LNDNSISSME AFKGVEKRLP NLKILYLGDN KIPSLAHLVV 300
LRNLSILELV LKNNPCRSRY KDSQQFISEV RRKFPKLVKL DGETLEPQIT FDLSEQGRLL 360
ETKASYLCDV AGAEVVRQFL DQYFRIFDSG NRQALLDAYH EKAMLSISMP SASQAGRLNS 420
FWKFNRNLRR LLNGEENRTR NLKYGRLACV STLDEWPKTQ HDRRTFTVDL TIYNTSMMVF 480
TVTGLFKELN DETNNPASME LYDVRHFART YVVVPQNNGF CIRNETIFIT NATHEQVREF 540
KRSQHQPAPG AMPSTSSAVT SPQAGAAAGL QGRLNALGVA TGPVAILSGD PLAATAPVNS 600
GSAAISTTAV APGAQDESTK MQMIEAMSAQ SQMNVIWSRK CLEETNWDFN HAAFVFEKLF 660
KENKIPPEAF MK 672 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:FlyBase.
 GO:0005654; C:nucleoplasm; IDA:FlyBase.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006378; P:mRNA polyadenylation; IMP:FlyBase.
 GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:FlyBase. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR002075; NTF2.
 IPR018222; Nuclear_transport_factor_2_euk.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR005637; TAP_C_dom.
 IPR015245; Tap_RNA-bd.
 IPR009060; UBA-like. 
Pfam
 PF02136; NTF2
 PF09162; Tap-RNA_bind
 PF03943; TAP_C 
SMART
 SM00804; TAP_C 
PROSITE
 PS51450; LRR
 PS50177; NTF2_DOMAIN
 PS50102; RRM
 PS51281; TAP_C 
PRINTS