CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043634
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Carnitine O-acetyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Crat 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
72GLERRAKKMENWLSEacetylation[1]
72GLERRAKKMENWLSEsuccinylation[1]
165SCRVPGPKQDSVVNFacetylation[1]
165SCRVPGPKQDSVVNFsuccinylation[1]
240NHRNTWAKAYNNLIKacetylation[1]
240NHRNTWAKAYNNLIKsuccinylation[1]
294MLHGGGSKFNSGNRWacetylation[1]
294MLHGGGSKFNSGNRWsuccinylation[1]
374EIKNDIEKAKQNLSIacetylation[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MKVSGRFKAH QDALPRLPVP PLQQSLDYYL KALQPIVSEE EWAHTKQLVD EFQTSGGVGE 60
RLQKGLERRA KKMENWLSEW WLKTAYLQFR QPVVIYSSPG VILPKQDFVD LQGQLRFAAK 120
LIEGVLDFKS MIDNETLPVE FLGGQPLCMN QYYQILSSCR VPGPKQDSVV NFLKSKRPPT 180
HITVVHNYQF FELDVYHSDG TPLTSDQIFV QLEKIWNSSL QSNKEPVGIL TSNHRNTWAK 240
AYNNLIKDKV NRESVNSIQK SIFTVCLDKQ VPRVSDDVYR NHVAGQMLHG GGSKFNSGNR 300
WFDKTLQFIV AEDGSCGMVY EHAAAEGPPI VALVDHVMEY TKKPELVRSP MVPLPMPKKL 360
RFNITPEIKN DIEKAKQNLS IMIQDLDIMM LTFHHFGKDF PKSEKLSPDA FIQVALQLAY 420
YRIYGQACAT YESASLRMFH LGRTDTIRSA SIDSLAFVKG MGDSTVPEQQ KVELLRKAVQ 480
AHRAYTDRAI RGEAFDRHLL GLKLQAIEDL VSMPDIFMDT SYAIAMHFNL STSQVPAKTD 540
CVMFFGPVVP DGYGICYNPM EAHINFSVSA YNSCAETNAA RMAHYLEKAL LDMRTLLQNH 600
PRAKL 605 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IEA:Compara.
 GO:0004092; F:carnitine O-acetyltransferase activity; IEA:Compara.
 GO:0019254; P:carnitine metabolic process, CoA-linked; IEA:Compara. 
Interpro
 IPR000542; Carn_acyl_trans. 
Pfam
 PF00755; Carn_acyltransf 
SMART
  
PROSITE
 PS00439; ACYLTRANSF_C_1
 PS00440; ACYLTRANSF_C_2 
PRINTS