CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021018
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 7 
Protein Synonyms/Alias
 Cytokeratin-7; CK-7; Keratin-7; K7; Type-II keratin Kb7 
Gene Name
 Krt7 
Gene Synonyms/Alias
 Krt2-7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
95QIKTLNNKFASFIDKubiquitination[1]
102KFASFIDKVRFLEQQubiquitination[1]
320QAEIDTLKNQRAKLEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Blocks interferon-dependent interphase and stimulates DNA synthesis in cells (By similarity). 
Sequence Annotation
 REGION 2 84 Head.
 REGION 84 120 Coil 1A.
 REGION 85 393 Rod.
 REGION 121 138 Linker 1.
 REGION 139 230 Coil 1B.
 REGION 231 254 Linker 12.
 REGION 255 393 Coil 2.
 REGION 394 457 Tail.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 15 15 Dimethylated arginine; alternate (By
 MOD_RES 15 15 Omega-N-methylarginine; alternate (By
 MOD_RES 173 173 N6-acetyllysine (By similarity).
 MOD_RES 246 246 Phosphoserine (By similarity).
 MOD_RES 248 248 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Keratin; Methylation; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 457 AA 
Protein Sequence
MSIHFSSRST AYPGRGAQVR LSSGRASFGS RSLYGLGSSR PRVAVRSAYG GPVGAGIREI 60
TINQSLLAPL SVDIDPTIQQ VRQEEREQIK TLNNKFASFI DKVRFLEQQN KMLETKWALL 120
QEQKSAKSSQ LPRIFEAQIA GLRQQLETLQ LDGGRLEVEL RNMQDVVEDF KNKYEEEINR 180
RTAAENEFVL LKKDVDAAYT NKVELEAKAD SLQDEINFLK TLHETELAEL QSQISDTSVV 240
LSMDNSRSLD LDGIIADVKA QYEEMANHSR AEAEAWYQTK FETLQAQAGK HGDDLRNTRN 300
EIAEMNRSIQ RLQAEIDTLK NQRAKLESSI AEAEEQGELA IKDAHAKQGE LEAALQKAKQ 360
DVARQLREYQ ELLNTKLALD IEIATYRKLL EGEESRLSGD GMGPVNISVV NSTGGNGGKL 420
IFGGTMGSNA LSFSGGPGAL RAYSIKTTST TRRGTHN 457 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0006417; P:regulation of translation; ISS:UniProtKB. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II.
 IPR009053; Prefoldin. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.