| Tag | Content |
|---|
| CPLM ID | CPLM-004690 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon-induced GTP-binding protein Mx1 |
Protein Synonyms/Alias | Myxoma resistance protein 1; Myxovirus resistance protein 1 |
Gene Name | Mx1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 397 | EESRLFTKLRNEFLA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity). |
Sequence Annotation | DOMAIN 564 652 GED.
NP_BIND 68 75 GTP (Potential).
NP_BIND 169 173 GTP (Potential).
NP_BIND 238 241 GTP (Potential).
REGION 60 331 GTPase domain (By similarity).
REGION 332 357 Bundle signaling element (BSE) (By
REGION 357 526 Middle domain (By similarity).
REGION 358 622 Stalk (By similarity). |
Keyword | Antiviral defense; Complete proteome; Direct protein sequencing; GTP-binding; Immunity; Innate immunity; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 652 AA |
Protein Sequence | MKERTSACRH GTPQKHPDTS EESQAMESVD NLCSQYEEKV RPCIDLIDSL RALGVEQDLA 60
LPAIAVIGDQ SSGKSSVLEA LSGVALPRGS GIVTRCPLVL KLKQLKQGEK WSGKVIYKDT 120
EIEISHPSLV EREINKAQNL IAGEGLKISS DLISLEVSSP HVPDLTLIDL PGITRVAVGD 180
QPADIEHKIK RLITEYIQKQ ETINLVVVPS NVDIATTEAL KMAQEVDPQG DRTIGILTKP 240
DLVDRGTEDK VVDVVRNLVC HLKKGYMIVK CRGQQDIQEQ LSLAEALQKE QVFFKEHPQF 300
RVLLEDGKAT VPCLAKRLTM ELTSHICKSL PILENQINVN HQIASEELQK YGADIPEDDS 360
KRLSFLMNKI NVFNKDILSL VQAQENISWE ESRLFTKLRN EFLAWNDYIE EHFKKTLGSS 420
EKHSQMEKFE SHYRGRELPG FVDYKAFENI IKKEVKALEE PALNMLHRVT TMVKNAFTKV 480
SSNNFGDFLN LHSTAKSKIE DIRFNQEKEA EKLIRLHFQM EHIVYCQDQA YKKALQEIRE 540
KEAEKEKSTF GAFQHNSPRK ELTTTEMTQH LNAYYQECGR NIGRQIPLII QYSILQTFGQ 600
EMEKAMLQLL QDTSKCNWFL TEQSDSREKK KFLKRRLLRL DEAQRKLAKF SN 652 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |