CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription activator BRG1 
Protein Synonyms/Alias
  
Gene Name
 Smarca4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
210TKATIELKALRLLNFubiquitination[1]
431VIHVESGKILTGTDAacetylation[2]
1191YSDSLTEKQWLKTLKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1267 AA 
Protein Sequence
XPDHLQMAVQ GKRPMPGMQQ QMPTLPPPSV SATGPGPGPG PGPGPGPGPA PPNYSRPHGM 60
GGPNMPPPGP SGVPPGMPGQ PPGGPPKPWP EGPMANAAAP TSTPQKLIPP QPTGRPSPAP 120
PAVPPAASPV MPPQTQSPGQ PAQPAPLVPL HQKQSRITPI QKPRGLDPVE ILQEREYRLQ 180
ARIAHRIQEL ENLPGSLAGD LRTKATIELK ALRLLNFQRQ LRQEVVVCMR RDTALETALN 240
AKAYKRSKRQ SLREARITEK LEKQQKIEQE RKRRQKHQEY LNSILQHAKD FREYHRSVTG 300
KLQKLTKAVA TYHANTEREQ KKENERIEKE RMRRLMAEDE EGYRKLIDQK KDKRLAYLLQ 360
QTDEYVANLT ELVRQHKAAQ VAKEKKKKKK KKKAENAEGQ TPAIGPDGEP LDETSQMSDL 420
PVKVIHVESG KILTGTDAPK AGQLEAWLEM NPGYEVAPRS DSEESGSEEE EEEEEEEQPQ 480
PAQPPTLPVE EKKKIPDPDS DDVSEVDARH IIENAKQDVD DEYGVSQALA RGLQSYYAVA 540
HAVTERVDKQ SALMVNGVLK QYQIKGLEWL VSLYNNNLNG ILADEMGLGK TIQTIALITY 600
LMEHKRINGP FLIIVPLSTL SNWAYEFDKW APSVVKVSYK GSPAARRAFV PQLRSGKFNV 660
LLTTYEYIIK DKHILAKIRW KYMIVDEGHR MKNHHCKLTQ VLNTHYVAPR RLLLTGTPLQ 720
NKLPELWALL NFLLPTIFKS CSTFEQWFNA PFAMTGEKVD LNEEETILII RRLHKVLRPF 780
LLRRLKKEVE AQLPEKVEYV IKCDMSALQR VLYRHMQAKG VLLTDGSEKD KKGKGGTKTL 840
MNTIMQLRKI CNHPYMFQHI EESFSEHLGF TGGIVQGLDL YRASGKFELL DRILPKLRAT 900
NHKVLLFCQM TSLMTIMEDY FAYRGFKYLR LDGTTKAEDR GMLLKTFNEP GSEYFIFLLS 960
TRAGGLGLNL QSADTVIIFD SDWNPHQDLQ AQDRAHRIGQ QNEVRVLRLC TVNSVEEKIL 1020
AAAKYKLNVD QKVIQAGMFD QKSSSHERRA FLQAILEHEE QDESRHCSTG SGSASFAHTA 1080
PPPAGVNPDL EEPPLKEEDE VPDDETVNQM IARHEEEFDL FMRMDLDRRR EEARNPKRKP 1140
RLMEEDELPS WIIKDDAEVE RLTCEEEEEK MFGRGSRHRK EVDYSDSLTE KQWLKTLKAI 1200
EEGTLEEIEE EVRQKKSSRK RKRDSEAGSS TPTTSTRSRD KDEESKKQKK RGRPPAEKLS 1260
PNPPNLT 1267 
Gene Ontology
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0005719; C:nuclear euchromatin; IDA:MGI.
 GO:0005726; C:perichromatin fibrils; IDA:MGI.
 GO:0016514; C:SWI/SNF complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IMP:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:MGI.
 GO:0035887; P:aortic smooth muscle cell differentiation; IMP:MGI.
 GO:0001832; P:blastocyst growth; IMP:MGI.
 GO:0001835; P:blastocyst hatching; IMP:MGI.
 GO:0000902; P:cell morphogenesis; IMP:MGI.
 GO:0006338; P:chromatin remodeling; IMP:MGI.
 GO:0060318; P:definitive erythrocyte differentiation; IMP:MGI.
 GO:0010424; P:DNA methylation on cytosine within a CG sequence; IMP:MGI.
 GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
 GO:0048562; P:embryonic organ morphogenesis; IMP:MGI.
 GO:0048730; P:epidermis morphogenesis; IMP:MGI.
 GO:0030198; P:extracellular matrix organization; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0007403; P:glial cell fate determination; IMP:MGI.
 GO:0060347; P:heart trabecula formation; IGI:MGI.
 GO:0030902; P:hindbrain development; IMP:MGI.
 GO:0043966; P:histone H3 acetylation; IMP:MGI.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0006346; P:methylation-dependent chromatin silencing; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006334; P:nucleosome assembly; TAS:MGI.
 GO:0043388; P:positive regulation of DNA binding; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0019827; P:stem cell maintenance; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI. 
Interpro
 IPR006576; BRK_domain.
 IPR013999; HAS_subgr.
 IPR014012; Helicase/SANT-assoc_DNA-bd.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR006562; HSA.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00271; Helicase_C
 PF07529; HSA
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00487; DEXDc
 SM00490; HELICc
 SM00573; HSA 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51204; HSA 
PRINTS