CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043588
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inactive phospholipase C-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 PLCL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
874PSVSLVMKDSFPYLEubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1012 AA 
Protein Sequence
MKNKLQDPSN QKCGGRKKTV SFSSMPSEKK ISSANDCISF MQAGCELKKV RPNSRIYNRF 60
FTLDTDLQAL RWEPSKKDLE KAKLDISAIK EIRLGKNTET FRNNGLADQI CEDCAFSILH 120
GENYESLDLV ANSADVANIW VSGLRYLVSR SKQPLDFMEG NQNTPRFMWL KTVFEAADVD 180
GNGIMLEDTS VELIKQLNPT LKEAKIRLKF KEIQKSKEKL TTRVTEEEFC EAFCELCTRP 240
EVYFLLVQIS KNKEYLDAND LMLFLEAEQG VTHITEDICL DIIRRYELSE EGRQKGFLAI 300
DGFTQYLLSS ECDIFDPEQK KVAQDMTQPL SHYYINASHN TYLIEDQFRG PADINGYIRA 360
LKMGCRSVEL DVSDGSDNEP ILCNRNNMTT HVSFRSVIEV INKFAFVASE YPLILCLGNH 420
CSLPQQKVMA QQMKKVFGNK LYTEAPLPSE SYLPSPEKLK RMIIVKGKKL PSDPDVLEGE 480
VTDEDEEAEM SRRMSVDYNG EQKQIRLCRE LSDLVSICKS VQYRDFELSM KSQNYWEMCS 540
FSETEASRIA NEYPEDFVNY NKKFLSRIYP SAMRIDSSNL NPQDFWNCGC QIVAMNFQTP 600
GPMMDLHTGW FLQNGGCGYV LRPSIMRDEV SYFSANTKGI LPGVSPLALH IKIISGQNFP 660
KPKGACAKGD VIDPYVCIEI HGIPADCSEQ RTKTVQQNSD NPIFDETFEF QVNLPELAMI 720
RFVVLDDDYI GDEFIGQYTI PFECLQPGYR HVPLRSFVGD IMEHVTLFVH IAITNRSGGG 780
KAQKRSLSVR MGKKVREYTM LRNIGLKTID DIFKIAVHPL REAIDMRENM QNAIVSIKEL 840
CGLPPIASLK QCLLTLSSRL ITSDNTPSVS LVMKDSFPYL EPLGAIPDVQ KKMLTAYDLM 900
IQESRFLIEM ADTVQEKIVQ CQKAGMEFHE ELHNLGAKEG LKGRKLNKAT ESFAWNITVL 960
KGQGDLLKNA KNEAIENMKQ IQLACLSCGL SKAPSSSAEA KSKRSLEAIE EK 1012 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR011993; PH_like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR001849; Pleckstrin_homology.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 
Pfam
 PF00168; C2
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 
SMART
 SM00239; C2
 SM00233; PH
 SM00148; PLCXc
 SM00149; PLCYc 
PROSITE
 PS50004; C2
 PS50003; PH_DOMAIN
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 
PRINTS
 PR00390; PHPHLIPASEC.