UniProt Accession

 FIP1_YEAST; P45976; D6VWR1 

Genbank Protein ID

 X83796; Z49593; BK006943 

Genbank Nucleotide ID

 CAA58727.1; CAA89621.1; DAA08877.1 

Protein Name

 Pre-mRNA polyadenylation factor FIP1 

Protein Synonyms/Alias

  

Gene Name

 FIP1 

Gene Synonyms/Alias

 YJR093C; J1911 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
47	PDIVKRQKFDSPVEE	acetylation	[1]
219	EYLHRQEKLQQDYNP	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Polymerase-regulating component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase PAP1. This inhibits the extension of an oligo(A) primer by limiting access of the RNA substrate to the C- terminal RNA binding domain of PAP1. Seems to tether PAP1 to the cleavage factor I. 

Sequence Annotation

 MOD_RES 50 50 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IDA:SGD.
 GO:0030674; F:protein binding, bridging; IMP:SGD.
 GO:0006379; P:mRNA cleavage; IDA:SGD.
 GO:0006378; P:mRNA polyadenylation; IDA:SGD. 

Interpro

 IPR007854; Fip1. 

Pfam

 PF05182; Fip1 

SMART

  

PROSITE

  

PRINTS