UniProt Accession

 INAR2_HUMAN; P48551; A8KAJ4; D3DSE8; D3DSE9; Q15467; Q6FHD7 

Genbank Protein ID

 X77722; L42243; L42238; L42239; L42240; L42323; L42241; L42242; L42243; L42238; L42239; L42240; L42323; L42241; L42243; L42238; L42239; L42240; L42323; L42241; L42242; L41942; L41943; L41944; U29584; X89814; X89772; AY740397; AK293059; CR541817; AP000292; AP000293; AP000294; AP000295; CH471079; CH471079; CH471079; CH471079 

Genbank Nucleotide ID

 CAA54785.1; AAB46417.1; AAB46417.1; AAB46417.1; AAB46417.1; AAB46417.1; AAB46417.1; AAB46417.1; AAB46418.1; AAB46418.1; AAB46418.1; AAB46418.1; AAB46418.1; AAB46418.1; AAB46419.1; AAB46419.1; AAB46419.1; AAB46419.1; AAB46419.1; AAB46419.1; AAB46419.1; AAB46413.1; AAB46414.1; AAB46415.1; AAC50202.1; CAA61940.1; CAA61914.1; AAU21038.1; BAF85748.1; CAG46616.1; EAX09842.1; EAX09843.1; EAX09844.1; EAX09846.1 

Protein Name

 Interferon alpha/beta receptor 2 

Protein Synonyms/Alias

 IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein; Type I interferon receptor 2 

Gene Name

 IFNAR2 

Gene Synonyms/Alias

 IFNABR; IFNARB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
286	VLRQGLAKGWNAVAI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. 

Sequence Annotation

 MOD_RES 400 400 Phosphoserine (By similarity).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...).
 CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...).
 DISULFID 39 122
 DISULFID 85 93
 DISULFID 207 227  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 515 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:ProtInc.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0004905; F:type I interferon receptor activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
 GO:0009615; P:response to virus; TAS:ProtInc.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR015373; Interferon_alpha/beta_rcpt_bsu. 

Pfam

 PF09294; Interfer-bind 

SMART

  

PROSITE

  

PRINTS