UniProt Accession

 TIM8B_HUMAN; Q9Y5J9; B0YJA5; Q3KQS9; Q9UN04 

Genbank Protein ID

 AF152350; AF150087; AK312169; EF445036; BC000711; BC105986; BC106067; AF165967 

Genbank Nucleotide ID

 AAF15100.1; AAD39994.1; BAG35103.1; ACA06083.1; AAH00711.1; AAI05987.1; AAI06068.1; AAD51801.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim8 B 

Protein Synonyms/Alias

 DDP-like protein; Deafness dystonia protein 2 

Gene Name

 TIMM8B 

Gene Synonyms/Alias

 DDP2; DDPL; TIM8B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	RFAQIVQKGGQ****	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). 

Sequence Annotation

 MOTIF 36 59 Twin CX3C motif.
 MOD_RES 2 2 N-acetylalanine.
 DISULFID 36 59 By similarity.
 DISULFID 40 55 By similarity.  

Keyword

 Acetylation; Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0042719; C:mitochondrial intermembrane space protein transporter complex; TAS:BHF-UCL.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0072321; P:chaperone-mediated protein transport; TAS:BHF-UCL.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome.
 GO:0007605; P:sensory perception of sound; TAS:ProtInc. 

Interpro

 IPR004217; Tim10/DDP_fam_Znf. 

Pfam

 PF02953; zf-Tim10_DDP 

SMART

  

PROSITE

  

PRINTS