UniProt Accession

 FBX21_HUMAN; O94952; B3KMF0; Q5BJG0; Q9H087 

Genbank Protein ID

 AF174601; AB020682; AK001699; AC026364; AC026368; CH471054; BC091496; AL136899 

Genbank Nucleotide ID

 AAF04522.1; BAA74898.1; BAG50962.1; EAW98105.1; AAH91496.1; CAB66833.2 

Protein Name

 F-box only protein 21 

Protein Synonyms/Alias

  

Gene Name

 FBXO21 

Gene Synonyms/Alias

 FBX21; KIAA0875 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	QSSGKVWKEQFRVRW	ubiquitination	[1]
101	VNWLEEYKVRQKAGL	ubiquitination	[2, 3]
397	GNLLSLGKREGIDQS	ubiquitination	[2]
482	TLEHIERKKEEVGVE	ubiquitination	[1]
483	LEHIERKKEEVGVEV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity). 

Sequence Annotation

 DOMAIN 28 84 F-box.  

Keyword

 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 628 AA 

Protein Sequence

Gene Ontology

 GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; NAS:UniProtKB. 

Interpro

 IPR001810; F-box_dom_cyclin-like.
 IPR011722; Hemimethylated_DNA-bd_dom. 

Pfam

 PF08755; YccV-like 

SMART

 SM00992; YccV-like 

PROSITE

 PS50181; FBOX 

PRINTS