CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prephenate dehydrogenase [NADP(+)] 
Protein Synonyms/Alias
 PRDH 
Gene Name
 TYR1 
Gene Synonyms/Alias
 YBR166C; YBR1218 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
97ATYGPSSKVGTIVGGubiquitination[1]
410ANFDIYKKQFQSVQKubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
 DOMAIN 14 297 Prephenate/arogenate dehydrogenase.
 NP_BIND 14 43 NADP (Potential).  
Keyword
 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Reference proteome; Tyrosine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MVSEDKIEQW KATKVIGIIG LGDMGLLYAN KFTDAGWGVI CCDREEYYDE LKEKYASAKF 60
ELVKNGHLVS RQSDYIIYSV EASNISKIVA TYGPSSKVGT IVGGQTSCKL PEIEAFEKYL 120
PKDCDIITVH SLHGPKVNTE GQPLVIINHR SQYPESFEFV NSVMACLKSK QVYLTYEEHD 180
KITADTQAVT HAAFLSMGSA WAKIKIYPWT LGVNKWYGGL ENVKVNISLR IYSNKWHVYA 240
GLAITNPSAH QQILQYATSA TELFSLMIDN KEQELTDRLL KAKQFVFGKH TGLLLLDDTI 300
LEKYSLSKSS IGNSNNCKPV PNSHLSLLAI VDSWFQLGID PYDHMICSTP LFRIFLGVSE 360
YLFLKPGLLE QTIDAAIHDK SFIKDDLEFV ISAREWSSVV SFANFDIYKK QFQSVQKFFE 420
PMLPEANLIG NEMIKTILSH SSDRSAAEKR NT 452 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0008977; F:prephenate dehydrogenase activity; ISS:SGD.
 GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006570; P:tyrosine metabolic process; NAS:SGD. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR003099; Prephen_DH.
 IPR012385; Prephenate_DH_fun. 
Pfam
 PF02153; PDH 
SMART
  
PROSITE
 PS51176; PDH_ADH 
PRINTS