UniProt Accession

 SAR1A_MOUSE; P36536 

Genbank Protein ID

 L20294 

Genbank Nucleotide ID

 AAA16323.1 

Protein Name

 GTP-binding protein SAR1a 

Protein Synonyms/Alias

  

Gene Name

 Sar1a 

Gene Synonyms/Alias

 Sara; Sara1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
146	TDAISEEKLREIKGL	acetylation	[1]
146	TDAISEEKLREIKGL	ubiquitination	[2]
182	VFMCSVLKRQGYGEG	acetylation	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). 

Sequence Annotation

 NP_BIND 32 39 GTP (By similarity).
 NP_BIND 75 78 GTP (By similarity).
 NP_BIND 134 137 GTP (By similarity).
 MOD_RES 139 139 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding; Nucleotide-binding; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IDA:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR006689; Small_GTPase_ARF/SAR.
 IPR006687; Small_GTPase_SAR1. 

Pfam

 PF00025; Arf 

SMART

 SM00178; SAR 

PROSITE

 PS51422; SAR1 

PRINTS

 PR00328; SAR1GTPBP.