| Tag | Content |
|---|
| CPLM ID | CPLM-003069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thymidylate synthase |
Protein Synonyms/Alias | TS; TSase |
Gene Name | thyA |
Gene Synonyms/Alias | b2827; JW2795 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 10 | QYLELMQKVLDEGTQ | acetylation | [1] | | 48 | GFPLVTTKRCHLRSI | acetylation | [1] | | 120 | TTVLNQLKNDPDSRR | acetylation | [1] | | 229 | REPRPLPKLIIKRKP | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation. |
Sequence Annotation | ACT_SITE 146 146
MOD_RES 1 1 N-formylmethionine (Probable). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Formylation; Methyltransferase; Nucleotide biosynthesis; Reference proteome; Repressor; RNA-binding; Transferase; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 264 AA |
Protein Sequence | MKQYLELMQK VLDEGTQKND RTGTGTLSIF GHQMRFNLQD GFPLVTTKRC HLRSIIHELL 60
WFLQGDTNIA YLHENNVTIW DEWADENGDL GPVYGKQWRA WPTPDGRHID QITTVLNQLK 120
NDPDSRRIIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS 180
YALLVHMMAQ QCDLEVGDFV WTGGDTHLYS NHMDQTHLQL SREPRPLPKL IIKRKPESIF 240
DYRFEDFEIE GYDPHPGIKA PVAI 264 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0004799; F:thymidylate synthase activity; IDA:EcoCyc. GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP. GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. |
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PRINTS | |