CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-associated protein 3 
Protein Synonyms/Alias
 KAP-3; KAP3 
Gene Name
 Kifap3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
477MLMKRALKLKDPLLMubiquitination[1]
630ATRDVIIKETQAPAYubiquitination[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. 
Sequence Annotation
 REPEAT 333 373 ARM 1.
 REPEAT 374 412 ARM 2.
 REPEAT 494 533 ARM 3.
 REPEAT 578 620 ARM 4.
 REPEAT 621 662 ARM 5.
 MOD_RES 60 60 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 793 AA 
Protein Sequence
MQGEDARYLK RKVKGGNIDV HPSEKALIVQ YEVEATILGE MGDPMLGERK ECQKIIRLKS 60
LNANTDITSL ARKVVEECKL IHPSKLSEVE QLLYYLQNRR DSLPGKEKKE KSSKPKDPPP 120
FEGMEIDEVA NINDMDEYIE LLYEDIPDKV RGSALILQLA RNPDNLEELL LNETALGALA 180
RVLREDWKQS VELATNIIYI FFCFSSFSHF HGLITHYKIG ALCMNIIDHE LKRHELWQEE 240
LSKKKKAVDE DLENQTLRKD YDKTFKKYQG LVVKQEQLLR VALYLLLNLA EDTRTELKMR 300
NKNIVHMLVK ALDRDNFELL ILVVSFLKKL SIFMENKNDM VEMDIVEKLV KMIPCEHEDL 360
LNITLRLLLN LSFDTGLRNK MVQVGLLPKL TALLGNENYK QIAMCVLYHI SMDDRFKSMF 420
AYTDCIPQLM KMLFECSDER IDLELISFCI NLAANKRNVQ LICEGNGLKM LMKRALKLKD 480
PLLMKMIRNI SQHDGPTKNL FIDYVGDLAA QISSDEEEEF VIECLGTLAN LTIPDLDWEL 540
VLKEYKLVPF LKDKLKPGAA EDDLVLEVVI MIGTVSMDDS CAALLAKSGI IPALIELLNA 600
QQEDDEFVCQ IIYVFYQMVF HQATRDVIIK ETQAPAYLID LMHDKNNEIR KVCDNTLDII 660
AEYDEEWAKK IQSEKFRWHN SQWLEMVESR QLDESEQYLY GDDRIEPYIH EGDILERPDL 720
FYNSDGLITS EGAISPDFFN DFHLQNGDVV GQHAFPGSLG MDGFGQPLGI LGRPATAYGF 780
RPDEPYYYSF GSR 793 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0000794; C:condensed nuclear chromosome; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016939; C:kinesin II complex; IPI:UniProtKB.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:MGI.
 GO:0007017; P:microtubule-based process; IPI:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0046587; P:positive regulation of calcium-dependent cell-cell adhesion; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0007266; P:Rho protein signal transduction; TAS:MGI. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo.
 IPR008658; KAP3. 
Pfam
  
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS