CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008026
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor SOX-9 
Protein Synonyms/Alias
  
Gene Name
 SOX9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61PKGEPDLKKESEEDKacetylation[1]
68KKESEEDKFPVCIREubiquitination[2]
82EAVSQVLKGYDWTLVubiquitination[3, 4]
122WAQAARRKLADQYPHubiquitination[2, 3, 4]
137LHNAELSKTLGKLWRubiquitination[2]
141ELSKTLGKLWRLLNEubiquitination[5, 6]
173KKDHPDYKYQPRRRKubiquitination[2, 3, 4]
249KTDVQPGKADLKREGubiquitination[3]
253QPGKADLKREGRPLPacetylation[1]
398QSQRTHIKTEQLSPSacetylation[1]
398QSQRTHIKTEQLSPSsumoylation[7]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] PIAS1 interacts with and represses SOX9 transactivation activity.
 Oh HJ, Kido T, Lau YF.
 Mol Reprod Dev. 2007 Nov;74(11):1446-55. [PMID: 17440973] 
Functional Description
 Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. 
Sequence Annotation
 DNA_BIND 105 173 HMG box.  
Keyword
 3D-structure; Complete proteome; Disease mutation; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE NTFPKGEPDL 60
KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR 120
RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK 180
SVKNGQAEAE EATEQTHISP NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT 240
PKTDVQPGKA DLKREGRPLP EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP 300
NGHPGVPATH GQVTYTGSYG ISSTAATPAS AGHVWMSKQQ APPPPPQQPP QAPPAPQAPP 360
QPQAAPPQQP AAPPQQPQAH TLTTLSSEPG QSQRTHIKTE QLSPSHYSEQ QQHSPQQIAY 420
SPFNLPHYSP SYPPITRSQY DYTDHQNSSS YYSHAAGQGT GLYSTFTYMN PAQRPMYTPI 480
ADTSGVPSIP QTHSPQHWEQ PVYTQLTRP 509 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0001158; F:enhancer sequence-specific DNA binding; ISS:UniProtKB.
 GO:0004672; F:protein kinase activity; ISS:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0060018; P:astrocyte fate commitment; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0019933; P:cAMP-mediated signaling; IDA:UniProtKB.
 GO:0001502; P:cartilage condensation; ISS:UniProtKB.
 GO:0001708; P:cell fate specification; ISS:UniProtKB.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.
 GO:0071504; P:cellular response to heparin; ISS:UniProtKB.
 GO:0071347; P:cellular response to interleukin-1; IEP:UniProtKB.
 GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.
 GO:0003413; P:chondrocyte differentiation involved in endochondral bone morphogenesis; IMP:UniProtKB.
 GO:0003415; P:chondrocyte hypertrophy; ISS:UniProtKB.
 GO:0006338; P:chromatin remodeling; IDA:UniProtKB.
 GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB.
 GO:0003203; P:endocardial cushion morphogenesis; ISS:UniProtKB.
 GO:0031018; P:endocrine pancreas development; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0060517; P:epithelial cell proliferation involved in prostatic bud elongation; ISS:UniProtKB.
 GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.
 GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0001942; P:hair follicle development; ISS:UniProtKB.
 GO:0003188; P:heart valve formation; IEA:Compara.
 GO:0003179; P:heart valve morphogenesis; ISS:UniProtKB.
 GO:0060729; P:intestinal epithelial structure maintenance; ISS:UniProtKB.
 GO:0035622; P:intrahepatic bile duct development; IEA:Compara.
 GO:0060174; P:limb bud formation; IEA:Compara.
 GO:0019100; P:male germ-line sex determination; ISS:UniProtKB.
 GO:0030879; P:mammary gland development; IEA:Compara.
 GO:0072289; P:metanephric nephron tubule formation; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0070168; P:negative regulation of biomineral tissue development; ISS:UniProtKB.
 GO:0030502; P:negative regulation of bone mineralization; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0032331; P:negative regulation of chondrocyte differentiation; ISS:UniProtKB.
 GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
 GO:0002683; P:negative regulation of immune system process; ISS:UniProtKB.
 GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
 GO:0030279; P:negative regulation of ossification; ISS:UniProtKB.
 GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0030903; P:notochord development; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IDA:UniProtKB.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0001503; P:ossification; IEA:Compara.
 GO:0030916; P:otic vesicle formation; ISS:UniProtKB.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0061036; P:positive regulation of cartilage development; IDA:UniProtKB.
 GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IEA:Compara.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:UniProtKB.
 GO:0030858; P:positive regulation of epithelial cell differentiation; ISS:UniProtKB.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:UniProtKB.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEP:UniProtKB.
 GO:2000020; P:positive regulation of male gonad development; IDA:UniProtKB.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISS:UniProtKB.
 GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IDA:UniProtKB.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
 GO:0006461; P:protein complex assembly; IDA:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0010564; P:regulation of cell cycle process; IMP:UniProtKB.
 GO:0060784; P:regulation of cell proliferation involved in tissue homeostasis; ISS:UniProtKB.
 GO:0072034; P:renal vesicle induction; ISS:UniProtKB.
 GO:0060221; P:retinal rod cell differentiation; ISS:UniProtKB.
 GO:0060009; P:Sertoli cell development; IEA:Compara.
 GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
 GO:0035019; P:somatic stem cell maintenance; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB.
 GO:0072197; P:ureter morphogenesis; IEA:Compara.
 GO:0072190; P:ureter urothelium development; IEA:Compara. 
Interpro
 IPR009071; HMG_box_dom.
 IPR022151; Sox_N. 
Pfam
 PF00505; HMG_box
 PF12444; Sox_N 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS