CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025709
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldehyde reductase 
Protein Synonyms/Alias
  
Gene Name
 Akr1a1 
Gene Synonyms/Alias
 Akr1a4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
13VLLHTGQKMPLIGLGubiquitination[1]
23LIGLGTWKSEPGQVKubiquitination[1]
30KSEPGQVKAAIKHALubiquitination[1]
34GQVKAAIKHALSAGYubiquitination[1]
68KESVGSGKAVPREELubiquitination[1]
85TSKLWNTKHHPEDVEubiquitination[1]
127RGDNPFPKNADGTVRubiquitination[1]
141RYDSTHYKETWKALEubiquitination[1]
145THYKETWKALEVLVAubiquitination[1]
153ALEVLVAKGLVKALGubiquitination[1]
157LVAKGLVKALGLSNFubiquitination[1]
240VVLALAEKHGRSPAQubiquitination[1]
263RKVICIPKSINPSRIubiquitination[1]
294KQLDALNKNWRYIVPubiquitination[1]
308PMITVDGKRVPRDAGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 50 50 Proton donor (By similarity).  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MTASSVLLHT GQKMPLIGLG TWKSEPGQVK AAIKHALSAG YRHIDCASVY GNETEIGEAL 60
KESVGSGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 120
GDNPFPKNAD GTVRYDSTHY KETWKALEVL VAKGLVKALG LSNFNSRQID DVLSVASVRP 180
AVLQVECHPY LAQNELIAHC HARGLEVTAY SPLGSSDRAW RHPDEPVLLE EPVVLALAEK 240
HGRSPAQILL RWQVQRKVIC IPKSINPSRI LQNIQVFDFT FSPEEMKQLD ALNKNWRYIV 300
PMITVDGKRV PRDAGHPLYP FNDPY 325 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.
 GO:0047939; F:L-glucuronate reductase activity; IDA:MGI.
 GO:0046185; P:aldehyde catabolic process; IDA:MGI.
 GO:0042840; P:D-glucuronate catabolic process; IDA:MGI.
 GO:0019853; P:L-ascorbic acid biosynthetic process; IDA:MGI. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.