| Tag | Content |
|---|
| CPLM ID | CPLM-018951 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-alpha-acetyltransferase 60 |
Protein Synonyms/Alias | dNaa60; NatF catalytic subunit |
Gene Name | CG18177 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 214 | YNIRGKGKDGFTYVN | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. Isoform A has histone acetyltransferase toward free histones, while isoform B has no histone acetyltransferase activity. |
Sequence Annotation | DOMAIN 34 239 N-acetyltransferase. |
Keyword | Acyltransferase; Alternative splicing; Chromatin regulator; Chromosome partition; Complete proteome; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 276 AA |
Protein Sequence | MAQFTLYNKH SAPPSSESTR VDCEHVPLCS INDVQLRFLV PDDLTEVRQL CQEWFPIDYP 60
LSWYEDITSS TRFFALAAVY NLAIIGLIVA EIKPYRNVNK EVIANMSDSD ELYTRLSGFP 120
MQDKGILPDS MGRSADVGYI LSLGVHRSHR RNGIGSLLLD ALMNHLTTAE RHSVKAIFLH 180
TLTTNQPAIF FYEKRRFTLH SFLPYYYNIR GKGKDGFTYV NYINGGHPPW TLLDHIKHYA 240
SMVRHTSSLC AWLAGRVQQV VRWFYHKLLT RFNFIE 276 |
Gene Ontology | GO:0005737; C:cytoplasm; IC:FlyBase. GO:0010485; F:H4 histone acetyltransferase activity; IDA:UniProtKB. GO:0004402; F:histone acetyltransferase activity; IEA:EC. GO:0004596; F:peptide alpha-N-acetyltransferase activity; IDA:UniProtKB. GO:0007059; P:chromosome segregation; IMP:UniProtKB. GO:0016573; P:histone acetylation; IEA:GOC. GO:0017196; P:N-terminal peptidyl-methionine acetylation; IDA:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |