CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022231
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SDA1 homolog 
Protein Synonyms/Alias
 Nucleolar protein 130; SDA1 domain-containing protein 1; hSDA 
Gene Name
 SDAD1 
Gene Synonyms/Alias
 NUC130 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21PQLQNLIKRDPPAYIubiquitination[1]
450NPQMLQKKFRGKPTEubiquitination[2]
454LQKKFRGKPTEASIEubiquitination[2]
558LTQEDFQKIRMAQMRubiquitination[2, 3]
643PFSSSTNKEKKKQKNacetylation[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity). 
Sequence Annotation
 MOD_RES 232 232 Phosphoserine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 585 585 Phosphoserine.
 MOD_RES 595 595 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Ribosome biogenesis; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 687 AA 
Protein Sequence
MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN KPSKELAELV 60
MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF CKALILLRNK NLINPSSLLE 120
LFFELFRCHD KLLRKTLYTH IVTDIKNINA KHKNNKVNVV LQNFMYTMLR DSNATAAKMS 180
LDVMIELYRR NIWNDAKTVN VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG 240
PTARDLLVQY ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL 300
LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV TKILLFAAQA 360
SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE ITARCPLAMT EELLQDLAQY 420
KTHKDKNVMM SARTLIHLFR TLNPQMLQKK FRGKPTEASI EARVQEYGEL DAKDYIPGAE 480
VLEVEKEENA ENDEDGWEST SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA 540
KAAAISTSRV LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE 600
RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN FMMMRYSQNV 660
RSKNKRSFRE KQLALRDALL KKRKRMK 687 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
 GO:0000055; P:ribosomal large subunit export from nucleus; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR027312; Sda1.
 IPR007949; SDA1_dom.
 IPR012977; Uncharacterised_NUC130/133_N. 
Pfam
 PF08158; NUC130_3NT
 PF05285; SDA1 
SMART
  
PROSITE
  
PRINTS