| Tag | Content |
|---|
| CPLM ID | CPLM-011113 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 8 |
Protein Synonyms/Alias | TAFII-65; TBP-associated factor 65 kDa; TBP-associated factor 8 |
Gene Name | TAF8 |
Gene Synonyms/Alias | TAF65; YML114C; YM8339.05C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 292 | LARERVTKFEVNQLK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. |
Sequence Annotation | DOMAIN 37 103 Histone-fold.
MOD_RES 269 269 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 510 AA |
Protein Sequence | MTSKTSESGT GTQSTIVQLR NLPDLTEISH LEIDAPVVEI LKKTVLFQLN SLNICISNFA 60
LDELVNLVTV QMDGMFRNLH NLTLLQRRSQ ASQADLKLLL REFNLDAPSL YQQFQASEFI 120
KSKHSTEYEK LMSWSSLAAL PHNEEDEEDE LNNIEEQQNE INVLLPPSNP LEKQIPSWLP 180
NFPPDHTYKF TPEFNHPITD LKTIKKEIVK ESQESEKALL NLNKSLSHIS SASNTPQPPG 240
LDDEDAIEQQ LEIWGNALEE RKPTITEKSF NENNIEQYAK YRVELARERV TKFEVNQLKR 300
TKNPFLKISE TLYLPESPHQ SHKTIQKTIE LQFRKSMTLF MHNLPKVQKL KKEKIRMAKE 360
ERAKSLKRRQ EELISQRTKR EQDEGHDLEL LLNNEHARDA ADDTTTPNAL NNSTIVINTN 420
AEDEDDDINL FGILGSSEDE NEMSSMPAEN LVAESEPPTM TAQDTTNTTP VAHNTTNIDA 480
TTSHSPHSTP NENAPTSPPA DIATDHDITM 510 |
Gene Ontology | GO:0005669; C:transcription factor TFIID complex; IDA:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IC:SGD. |
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