UniProt Accession

 SIX3_HUMAN; O95343; D6W5A5; Q53T42 

Genbank Protein ID

 AF092047; AF049339; AF083891; AJ012611; AC012354; CH471053; CH471053 

Genbank Nucleotide ID

 AAD11939.1; AAD15753.1; AAD51091.1; CAB42539.1; AAX93283.1; EAX00267.1; EAX00268.1 

Protein Name

 Homeobox protein SIX3 

Protein Synonyms/Alias

 Sine oculis homeobox homolog 3 

Gene Name

 SIX3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
209	TIWDGEQKTHCFKER	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be involved in visual system development. 

Sequence Annotation

 DNA_BIND 206 265 Homeobox.  

Keyword

 Complete proteome; Developmental protein; Disease mutation; DNA-binding; Holoprosencephaly; Homeobox; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0007420; P:brain development; TAS:ProtInc.
 GO:0048512; P:circadian behavior; IEA:Compara.
 GO:0021536; P:diencephalon development; IEA:Compara.
 GO:0021797; P:forebrain anterior/posterior pattern specification; IEA:Compara.
 GO:0060235; P:lens induction in camera-type eye; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS