CPLM-004605

Genbank Nucleotide ID

Protein Synonyms/Alias

Hexokinase type I; HK I; Hexokinase, tumor isozyme

Mus musculus (Mouse)

Position	Peptide	Type	References
21	LKDDQVKKIDKYLYA	ubiquitination	[1]
24	DQVKKIDKYLYAMRL	ubiquitination	[1]
62	YNPTASVKMLPTFVR	ubiquitination	[1]
77	SIPDGSEKGDFIALD	ubiquitination	[1]
147	KRKIKDKKLPVGFTF	ubiquitination	[1]
187	VEGADVVKLLNKAIK	ubiquitination	[1]
315	LILVKMAKESLLFEG	ubiquitination	[1]
333	PELLTRGKFTTSDVA	ubiquitination	[1]
346	VAAIETDKEGVQNAK	ubiquitination	[1]
418	GVDGSLYKMHPQYSR	ubiquitination	[1]
451	LSESGSGKGAAMVTA	ubiquitination	[1]
488	KQALMEVKKKLRSEM	ubiquitination	[1]
510	TNSRATVKMLPSYVR	ubiquitination	[1]
624	ITWTKGFKATDCVGH	ubiquitination	[1]
763	NILIDFTKKGFLFRG	ubiquitination	[1]
777	GQISEPLKTRGIFET	ubiquitination	[1]
828	TVCGVVSKRAAQLCG	ubiquitination	[1]
844	GMAAVVEKIRENRGL	ubiquitination	[1]
885	TVKELSPKCTVSFLL	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

NP_BIND 140 145 ATP 1 (Potential).
NP_BIND 481 482 ATP 1 (By similarity).
NP_BIND 588 593 ATP 2 (By similarity).
NP_BIND 803 804 ATP 2 (By similarity).
NP_BIND 840 844 ATP 2 (By similarity).
NP_BIND 919 923 ATP 2 (By similarity).
REGION 1 52 Hydrophobic.
REGION 53 531 Regulatory.
REGION 140 144 Glucose-6-phosphate 1 binding (By
REGION 228 229 Substrate 1 binding (By similarity).
REGION 264 265 Substrate 1 binding (By similarity).
REGION 347 350 Substrate 1 binding (By similarity).
REGION 469 471 Glucose-6-phosphate 1 binding (By
REGION 532 974 Catalytic.
REGION 588 592 Glucose-6-phosphate 2 binding (By
REGION 659 660 Substrate 2 binding (By similarity).
REGION 676 677 Substrate 2 binding (By similarity).
REGION 712 713 Substrate 2 binding (By similarity).
REGION 917 919 Glucose-6-phosphate 2 binding (By
BINDING 86 86 ATP 1 (By similarity).
BINDING 211 211 Substrate 1 (By similarity).
BINDING 265 265 Glucose-6-phosphate 1 (By similarity).
BINDING 288 288 Glucose-6-phosphate 1 (By similarity).
BINDING 291 291 Substrate 1 (By similarity).
BINDING 316 316 Substrate 1 (By similarity).
BINDING 505 505 Glucose-6-phosphate 1 (By similarity).
BINDING 659 659 Glucose-6-phosphate 2 (By similarity).
BINDING 713 713 Glucose-6-phosphate 2 (By similarity).
BINDING 736 736 ATP 2 (By similarity).
BINDING 736 736 Glucose-6-phosphate 2 (By similarity).
BINDING 739 739 Substrate 2 (By similarity).
BINDING 764 764 Substrate 2 (By similarity).
BINDING 798 798 Substrate 2 (By similarity).
BINDING 953 953 Glucose-6-phosphate 2 (By similarity).
MOD_RES 83 83 Phosphotyrosine.

Allosteric enzyme; Alternative initiation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Glycolysis; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transferase.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; IDA:MGI.
GO:0045121; C:membrane raft; IDA:MGI.
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005634; C:nucleus; IEA:Compara.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008865; F:fructokinase activity; IBA:RefGenome.
GO:0004340; F:glucokinase activity; IBA:RefGenome.
GO:0019158; F:mannokinase activity; IBA:RefGenome.
GO:0001678; P:cellular glucose homeostasis; IBA:RefGenome.
GO:0006096; P:glycolysis; TAS:MGI.

IPR001312; Hexokinase.
IPR022673; Hexokinase_C.
IPR019807; Hexokinase_CS.
IPR022672; Hexokinase_N.

PF00349; Hexokinase_1
PF03727; Hexokinase_2

PS00378; HEXOKINASES

PR00475; HEXOKINASE.