UniProt Accession

 ROA3_RAT; Q6URK4; Q6URK3 

Genbank Protein ID

 AY363226; AY363227; BC081878 

Genbank Nucleotide ID

 AAQ63630.1; AAQ63631.1; AAH81878.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A3 

Protein Synonyms/Alias

 hnRNP A3 

Gene Name

 Hnrnpa3 

Gene Synonyms/Alias

 Hnrpa3 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MEVKPPPGRPQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. 

Sequence Annotation

 DOMAIN 35 118 RRM 1.
 DOMAIN 126 205 RRM 2.
 MOD_RES 52 52 Dimethylated arginine; alternate (By
 MOD_RES 52 52 Omega-N-methylarginine; alternate (By
 MOD_RES 134 134 N6-acetyllysine (By similarity).
 MOD_RES 246 246 Dimethylated arginine (By similarity).
 MOD_RES 351 351 Phosphoserine (By similarity).
 MOD_RES 356 356 Phosphoserine (By similarity).
 MOD_RES 359 359 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphotyrosine (By similarity).
 MOD_RES 365 365 Phosphotyrosine (By similarity).
 MOD_RES 367 367 Phosphoserine (By similarity).
 MOD_RES 371 371 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0035770; C:ribonucleoprotein granule; IDA:RGD.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; IMP:RGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0051033; F:RNA transmembrane transporter activity; IMP:RGD.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IMP:RGD.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS