UniProt Accession

 CDC42_YEAST; P19073; D6VYN1; Q05978 

Genbank Protein ID

 X51906; U19027; AY557933; BK006945 

Genbank Nucleotide ID

 CAA36186.1; AAB67416.1; AAS56259.1; DAA09547.1 

Protein Name

 Cell division control protein 42 

Protein Synonyms/Alias

 Suppressor of RHO3 protein 2 

Gene Name

 CDC42 

Gene Synonyms/Alias

 SRO2; YLR229C; L8083.13 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
123	QIDLRDDKVIIEKLQ	ubiquitination	[1]
153	ARELKAVKYVECSAL	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 115 118 GTP (By similarity).
 MOTIF 32 40 Effector region (Potential).
 MOD_RES 188 188 Cysteine methyl ester (By similarity).
 LIPID 188 188 S-geranylgeranyl cysteine (By  

Keyword

 Cell cycle; Cell division; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Pheromone response; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0031965; C:nuclear membrane; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0004871; F:signal transducer activity; TAS:SGD.
 GO:0007118; P:budding cell apical bud growth; IMP:SGD.
 GO:0007119; P:budding cell isotropic bud growth; IMP:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0030010; P:establishment of cell polarity; IMP:SGD.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IGI:SGD.
 GO:0045921; P:positive regulation of exocytosis; IMP:SGD.
 GO:0007124; P:pseudohyphal growth; IMP:SGD.
 GO:0007096; P:regulation of exit from mitosis; IMP:SGD.
 GO:0060178; P:regulation of exocyst localization; IMP:SGD.
 GO:0031384; P:regulation of initiation of mating projection growth; IMP:SGD.
 GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD.
 GO:0007266; P:Rho protein signal transduction; TAS:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.