| Tag | Content |
|---|
| CPLM ID | CPLM-020825 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coiled-coil domain-containing protein 39 |
Protein Synonyms/Alias | |
Gene Name | Ccdc39 |
Gene Synonyms/Alias | D3Ertd789e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 551 | EKELSKAKAVKEDMM | acetylation | [1] | | 554 | LSKAKAVKEDMMIED | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly (By similarity). |
Sequence Annotation | |
Keyword | Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 937 AA |
Protein Sequence | MCSEFLSELH WEDGFAIPVA NQENKILEDQ LAKLREEKSN LQDQLHDYEE RINSMTSHLK 60
NVNQEFLFTQ SLYKARESEI ESEEHFKAIA ERELGRVKNE TQLLEKEMAI IRERKSQMEN 120
NIFKTTQKLD DLKCQMNWDQ QALEAWLEES AHKDSDSLTL QKYSQQDDNK IRALTLQLEK 180
LTMEYNEKRK LLDSELTETL SAQLELDKAA QDFRKIHLER QELIQQWENT IEQMQRRDQE 240
IDNCALALSR IKQEAREKEG VVKEKIKFLE NEVENNIEYE RKISVAERKV SKCRMDYQRH 300
EGNRSQLKDE LDTLKTTLNR TSSDLQALRK NISKVKKDIF DETLRLQKLK HHNEVVKHKL 360
KMITEKTLSI EEKATNMEDM LKEEEKGLKE VEVQLGIVKD VLFKKVQELQ NEIAKEKALV 420
SEIEGTRSSL KHLNKQLHKL DFETLKQQEI MYSQDFYIQQ VERRMSRLKG EINSEEKQAL 480
EAKILELKKT MDEKKSTLSL LESQIKKLHN DLYFIKKSNG KNNDEKESLM NKISELNLFI 540
DRSEKELSKA KAVKEDMMIE DNLLKLQVKR ARELLYSKAE EVLSLEKRKQ QLGKDMEERA 600
EEIKVHKAML TSQIRCVEQQ RKTMSSEFHE RLSKIDKLKN RYEILTVVML PPEGEEEKTQ 660
SYYVIKAAQE KEELQREGDS LDAKINKAEK EIYALQNTLQ VLNSCNSNYK QSFKKVTPSS 720
DEYALKIQLE EQKRTADERY RCKQRQIREL QEDIQSMENT FEVIGHLANN AKEKLTEKQT 780
LAFQLRKETE EQKPKLQRIT KQCGRLRREI RILKQTDNET LEEQDIQLRE IIQFHKDIDQ 840
MLVNAMENAE IHAIFKTYFE QNGLELPTAR GPSSRSSSQS SSLSSFRSLE DVTLQSPPTA 900
KVIQLRFPEP PPATNDSSRS ASSGSNSNIP KEKKLSK 937 |
Gene Ontology | GO:0035085; C:cilium axoneme; ISS:UniProtKB. GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW. GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB. GO:0060285; P:ciliary cell motility; ISS:UniProtKB. GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB. GO:0060286; P:flagellar cell motility; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |