UniProt Accession

 ACO13_HUMAN; Q9NPJ3; F5H2L4; O95549 

Genbank Protein ID

 AF155649; AF220186; AF274952; AK000508; AK309738; AL031775; BC000894 

Genbank Nucleotide ID

 AAF67006.1; AAF67651.1; AAK07529.1; BAA91215.1; CAD92509.1; AAH00894.1 

Protein Name

 Acyl-coenzyme A thioesterase 13 

Protein Synonyms/Alias

 Acyl-CoA thioesterase 13; Thioesterase superfamily member 2 

Gene Name

 ACOT13 

Gene Synonyms/Alias

 THEM2; HT012; PNAS-27 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	NFERVLGKITLVSAA	ubiquitination	[1]
111	AHVLKQGKTLAFTSV	ubiquitination	[1]
123	TSVDLTNKATGKLIA	ubiquitination	[1]
127	LTNKATGKLIAQGRH	acetylation	[2]
127	LTNKATGKLIAQGRH	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro). 

Sequence Annotation

 BINDING 50 50 Substrate.
 MOD_RES 2 2 N-acetylthreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0047617; F:acyl-CoA hydrolase activity; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IPI:UniProtKB. 

Interpro

 IPR003736; PAAI_dom.
 IPR006683; Thioestr_supf. 

Pfam

 PF03061; 4HBT 

SMART

  

PROSITE

  

PRINTS