UniProt Accession

 GLO2_ECOLI; P0AC84; Q47677 

Genbank Protein ID

 U70214; U00096; AP009048 

Genbank Nucleotide ID

 AAB08634.1; AAC73317.1; BAA77883.1 

Protein Name

 Hydroxyacylglutathione hydrolase 

Protein Synonyms/Alias

 Glyoxalase II; Glx II 

Gene Name

 gloB 

Gene Synonyms/Alias

 yafR; b0212; JW0202 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
68	GVKELVEKFPQIVVY	acetylation	[1]
83	GPQETQDKGTTQVVK	acetylation	[1]
198	KVKELRAKNQITLPV	acetylation	[1]
208	ITLPVILKNERQINV	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. 

Sequence Annotation

 METAL 53 53 Zinc 1 (By similarity).
 METAL 55 55 Zinc 1 (By similarity).
 METAL 57 57 Zinc 2 (By similarity).
 METAL 58 58 Zinc 2 (By similarity).
 METAL 110 110 Zinc 1 (By similarity).
 METAL 127 127 Zinc 1 (By similarity).
 METAL 127 127 Zinc 2 (By similarity).
 METAL 165 165 Zinc 2 (By similarity).  

Keyword

 Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0006750; P:glutathione biosynthetic process; IEA:InterPro.
 GO:0019243; P:methylglyoxal catabolic process to D-lactate; IDA:EcoCyc. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS