UniProt Accession

 FABG_BACSU; P51831; O31733 

Genbank Protein ID

 U59433; AL009126; Y13937; D64116 

Genbank Nucleotide ID

 AAC44307.1; CAB13464.1; CAA74250.1; BAA10974.1 

Protein Name

 3-oxoacyl-[acyl-carrier-protein] reductase FabG 

Protein Synonyms/Alias

 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase 

Gene Name

 fabG 

Gene Synonyms/Alias

 ylpF; BSU15910 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
197	DMTDKLAKDVQDEML	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity). 

Sequence Annotation

 NP_BIND 11 14 NADP (By similarity).
 NP_BIND 62 63 NADP (By similarity).
 NP_BIND 154 158 NADP (By similarity).
 ACT_SITE 154 154 Proton acceptor (By similarity).
 BINDING 36 36 NADP (By similarity).
 BINDING 89 89 NADP; via carbonyl oxygen (By
 BINDING 141 141 Substrate (By similarity).
 BINDING 187 187 NADP; via amide nitrogen and carbonyl  

Keyword

 Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:EC.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR011284; 3oxo_ACP_reduc.
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.