UniProt Accession

 RGS5_HUMAN; O15539; E9PMP5; Q53XA9; Q599J0 

Genbank Protein ID

 AF030108; AB008109; AF159570; AJ891044; AF493929; BX537427; AL451063; AL499616; AL583850; AL583850; AL451063; AL499616; AL499616; AL451063; AL583850; CH471067; BC030059; BU172751 

Genbank Nucleotide ID

 AAB84001.1; BAA22889.1; AAD40957.1; CAI76926.1; AAM12643.1; CAD97669.1; CAH71851.1; CAH71851.1; CAH71851.1; CAH73764.1; CAH73764.1; CAH73764.1; CAI15095.1; CAI15095.1; CAI15095.1; EAW90731.1; AAH30059.1 

Protein Name

 Regulator of G-protein signaling 5 

Protein Synonyms/Alias

 RGS5 

Gene Name

 RGS5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	RAKEIKIKLGILLQK	ubiquitination	[1]
29	KLGILLQKPDSVGDL	ubiquitination	[1]
43	LVIPYNEKPEKPAKT	ubiquitination	[1]
46	PYNEKPEKPAKTQKT	ubiquitination	[1]
52	EKPAKTQKTSLDEAL	ubiquitination	[1]
67	QWRDSLDKLLQNNYG	ubiquitination	[1]
79	NYGLASFKSFLKSEF	ubiquitination	[1]
114	AKMAEKAKQIYEEFI	ubiquitination	[1]
127	FIQTEAPKEVNIDHF	ubiquitination	[1]
136	VNIDHFTKDITMKNL	ubiquitination	[1]
141	FTKDITMKNLVEPSL	ubiquitination	[1]
156	SSFDMAQKRIHALME	ubiquitination	[1]
164	RIHALMEKDSLPRFV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). 

Sequence Annotation

 DOMAIN 64 180 RGS.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
 GO:0007165; P:signal transduction; IEA:Compara.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 

Pfam

 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.