CPLM-014736

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014736

UniProt Accession

ANKS6_HUMAN; Q68DC2; A0SE62; Q5VSL0; Q5VSL2; Q5VSL3; Q5VSL4; Q68DB8; Q6P2R2; Q8N9L6; Q96D62

Genbank Protein ID

DQ309791; DQ309777; DQ309778; DQ309779; DQ309780; DQ309781; DQ309782; DQ309783; DQ309784; DQ309785; DQ309786; DQ309787; DQ309788; DQ309789; DQ309790; AL353782; AL807776; AL353782; AL807776; AL353782; AL807776; AL807776; AL353782; AL807776; AL353782; AL807776; AL353782; CR749467; CR749472; BC064367; AK094247

Genbank Nucleotide ID

ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; ABC48694.1; CAH71295.2; CAH71295.2; CAH71296.2; CAH71296.2; CAM14169.1; CAM14169.1; CAH69985.2; CAH69985.2; CAH69986.2; CAH69986.2; CAM13062.1; CAM13062.1; CAH18298.1; CAH18302.1; AAH64367.1; BAC04317.1

Protein Name

Ankyrin repeat and SAM domain-containing protein 6

Protein Synonyms/Alias

Ankyrin repeat domain-containing protein 14; SamCystin; Sterile alpha motif domain-containing protein 6; SAM domain-containing protein 6

Gene Name

ANKS6

Gene Synonyms/Alias

ANKRD14; SAMD6

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
247	VAQQLVEKGANPDHL	ubiquitination	[1]
269	FEVALDCKHRDLVDY	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Required for renal function (By similarity).

Sequence Annotation

REPEAT 8 37 ANK 1.
REPEAT 77 106 ANK 2.
REPEAT 110 139 ANK 3.
REPEAT 143 172 ANK 4.
REPEAT 190 219 ANK 5.
REPEAT 224 253 ANK 6.
REPEAT 257 289 ANK 7.
REPEAT 291 321 ANK 8.
REPEAT 325 354 ANK 9.
REPEAT 359 388 ANK 10.
REPEAT 392 423 ANK 11.
DOMAIN 773 836 SAM.

Keyword

Alternative splicing; ANK repeat; Complete proteome; Polymorphism; Reference proteome; Repeat.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

871 AA

Protein Sequence

MGEGGLPPAF QLLLRACDQG DTETARRLLE PGAAEPAERG AEPEAGAEPA GAEVAGPGAA 60
AAGAVGAPVP VDCSDEAGNT ALQFAAAGGH EPLVRFLLRR GASVNSRNHY GWSALMQAAR 120
FGHVSVAHLL LDHGADVNAQ NRLGASVLTV ASRGGHLGVV KLLLEAGAFV DHHHPSGEQL 180
GLGGSRDEPL DITALMAAIQ HGHEAVVRLL MEWGADPNHA ARTVGWSPLM LAALTGRLGV 240
AQQLVEKGAN PDHLSVLEKT AFEVALDCKH RDLVDYLDPL TTVRPKTDEE KRRPDIFHAL 300
KMGNFQLVKE IADEDPSHVN LVNGDGATPL MLAAVTGQLA LVQLLVERHA DVDKQDSVHG 360
WTALMQATYH GNKEIVKYLL NQGADVTLRA KNGYTAFDLV MLLNDPDTEL VRLLASVCMQ 420
VNKDKGRPSH QPPLPHSKVR QPWSIPVLPD DKGGLKSWWN RMSNRFRKLK LMQTLPRGLS 480
SNQPLPFSDE PEPALDSTMR AAPQDKTSRS ALPDAAPVTK DNGPGSTRGE KEDTLLTTML 540
RNGAPLTRLP SDKLKAVIPP FLPPSSFELW SSDRSRTRHN GKADPMKTAL PQRASRGHPV 600
GGGGTDTTPV RPVKFPSLPR SPASSANSGN FNHSPHSSGG SSGVGVSRHG GELLNRSGGS 660
IDNVLSQIAA QRKKAAGLLE QKPSHRSSPV GPAPGSSPSE LPASPAGGSA PVGKQKLETS 720
KRPPSGTSTT SKSTSPTLTP SPSPKGHTAE SSVSSSSSHR QSKSSGGSSS GTITDEDELT 780
GILKKLSLEK YQPIFEEQEV DMEAFLTLTD GDLKELGIKT DGSRQQILAA ISELNAGKGR 840
ERQILQETIH NFHSSFESSA SNTRAPGNSP CA 872

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Compara.

Interpro

IPR002110; Ankyrin_rpt.
IPR020683; Ankyrin_rpt-contain_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.

Pfam

PF12796; Ank_2
PF00536; SAM_1

SMART

SM00248; ANK
SM00454; SAM

PROSITE

PS50297; ANK_REP_REGION
PS50088; ANK_REPEAT
PS50105; SAM_DOMAIN

PRINTS

PR01415; ANKYRIN.