UniProt Accession

 CHTOP_HUMAN; Q9Y3Y2; D3DV55; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0 

Genbank Protein ID

 AF261137; AF318362; AL162258; AL162258; AL162258; CH471121; CH471121; BC002733; BC059949; BC070027; BC108721; BC120961; BC120962; AL050260; AL512704 

Genbank Nucleotide ID

 AAG44673.1; AAL55869.1; CAI19678.1; CAI19679.1; CAI19680.1; EAW53290.1; EAW53295.1; AAH02733.1; AAH59949.1; AAH70027.1; AAI08722.1; AAI20962.1; AAI20963.1; CAB43362.2; CAC21650.2 

Protein Name

 Chromatin target of PRMT1 protein 

Protein Synonyms/Alias

 Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG 

Gene Name

 CHTOP 

Gene Synonyms/Alias

 C1orf77; FOP; HT031; PP7704 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MAAQSAPKVVLKSTT	ubiquitination	[1]
16	VVLKSTTKMSLNERF	ubiquitination	[2]
28	ERFTNMLKNKQPTPV	ubiquitination	[2]
30	FTNMLKNKQPTPVNI	ubiquitination	[2]
70	PSVQAALKLKQKSLK	ubiquitination	[2, 3]
72	VQAALKLKQKSLKQR	ubiquitination	[2]
82	SLKQRLGKSNIQARL	ubiquitination	[2, 3]
214	LARPVLTKEQLDNQL	ubiquitination	[1, 3]
227	QLDAYMSKTKGHLDA	ubiquitination	[1, 2, 3, 4]
229	DAYMSKTKGHLDAEL	ubiquitination	[2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. 

Sequence Annotation

 REGION 153 206 Interaction with PRMT1 (By similarity).
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 242 242 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR025715; FoP_duplication. 

Pfam

 PF13865; FoP_duplication 

SMART

  

PROSITE

  

PRINTS