UniProt Accession

 PODXL_MOUSE; Q9R0M4; Q9ESZ1 

Genbank Protein ID

 AB028048; AF290209; BC052442; BC054530 

Genbank Nucleotide ID

 BAA86912.1; AAG02458.1; AAH52442.1; AAH54530.1 

Protein Name

 Podocalyxin 

Protein Synonyms/Alias

 Podocalyxin-like protein 1; PC; PCLP-1 

Gene Name

 Podxl 

Gene Synonyms/Alias

 Pclp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
470	TPSEMQEKKVVNLNG	ubiquitination	[1]
471	PSEMQEKKVVNLNGE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. 

Sequence Annotation

 MOD_RES 482 482 Phosphoserine (By similarity).
 MOD_RES 501 501 Phosphothreonine (By similarity).
 CARBOHYD 25 25 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 154 154 N-linked (GlcNAc...) (Potential).
 CARBOHYD 167 167 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 303 303 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell adhesion; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 503 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0030175; C:filopodium; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0031528; C:microvillus membrane; IDA:UniProtKB.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0036057; C:slit diaphragm; ISS:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0072175; P:epithelial tube formation; ISS:UniProtKB.
 GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.
 GO:0050900; P:leukocyte migration; IMP:MGI.
 GO:0022408; P:negative regulation of cell-cell adhesion; IMP:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
 GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; ISS:UniProtKB.
 GO:0032534; P:regulation of microvillus assembly; IDA:UniProtKB. 

Interpro

 IPR013836; CD34/Podocalyxin.
 IPR017403; Podocalyxin-like_p1. 

Pfam

 PF06365; CD34_antigen 

SMART

  

PROSITE

  

PRINTS