CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase C 
Protein Synonyms/Alias
  
Gene Name
 Prkca 
Gene Synonyms/Alias
 mCG_140727 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
199SDPYVKLKLIPDPKNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 672 AA 
Protein Sequence
MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
PQFVHPILQS AV 672 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001750; C:photoreceptor outer segment; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004698; F:calcium-dependent protein kinase C activity; IDA:MGI.
 GO:0035403; F:histone kinase activity (H3-T6 specific); IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0071322; P:cellular response to carbohydrate stimulus; IDA:MGI.
 GO:0002062; P:chondrocyte differentiation; IDA:MGI.
 GO:0002159; P:desmosome assembly; IEA:Compara.
 GO:0000188; P:inactivation of MAPK activity; IMP:MGI.
 GO:0050930; P:induction of positive chemotaxis; IMP:MGI.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO:0034351; P:negative regulation of glial cell apoptotic process; IEA:Compara.
 GO:0046325; P:negative regulation of glucose import; IMP:MGI.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:MGI.
 GO:0030593; P:neutrophil chemotaxis; IMP:MGI.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0045785; P:positive regulation of cell adhesion; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IMP:MGI.
 GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI.
 GO:0006937; P:regulation of muscle contraction; IMP:MGI.
 GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.
 GO:0090330; P:regulation of platelet aggregation; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0070555; P:response to interleukin-1; IEA:Compara. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR020454; DAG/PE-bd.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR014375; Protein_kinase_C_a/b/g.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00109; C1
 SM00239; C2
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50004; C2
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.
 PR00008; DAGPEDOMAIN.