UniProt Accession

 KAD6_HUMAN; Q9Y3D8; A8MSZ6; Q5F2S9 

Genbank Protein ID

 AJ878880; AJ878881; AF151895; AF110777; AC145132; CH471137; CH471137; CH471137; CH471137; BC007349; BC007426 

Genbank Nucleotide ID

 CAI48030.1; CAI48031.1; AAD34132.1; AAF14860.1; EAW51290.1; EAW51291.1; EAW51292.1; EAW51297.1; AAH07349.1; AAH07426.1 

Protein Name

 Adenylate kinase isoenzyme 6 

Protein Synonyms/Alias

 AK6; Adrenal gland protein AD-004; Coilin-interacting nuclear ATPase protein; hCINAP; Dual activity adenylate kinase/ATPase; AK/ATPase 

Gene Name

 TAF9 

Gene Synonyms/Alias

 AK6; CINAP; AD-004; CGI-137 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	TGTPGVGKTTLGKEL	ubiquitination	[1]
21	VGKTTLGKELASKSG	ubiquitination	[1]
26	LGKELASKSGLKYIN	ubiquitination	[1]
30	LASKSGLKYINVGDL	ubiquitination	[1, 2]
168	KWIEQWIKDHNS***	ubiquitination	[1, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. 

Sequence Annotation

 NP_BIND 13 18 ATP.
 NP_BIND 148 149 ATP.
 REGION 33 56 NMPbind.
 REGION 108 118 LID.
 BINDING 39 39 AMP (Probable).
 BINDING 79 79 ATP.
 BINDING 105 105 ATP.
 BINDING 109 109 ATP.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IDA:UniProtKB.
 GO:0004017; F:adenylate kinase activity; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS