CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000626
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myb-binding protein 1A 
Protein Synonyms/Alias
 PAR-interacting protein; PIP 
Gene Name
 Mybbp1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
162MKCVRLLKILSHHYNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). 
Sequence Annotation
 REGION 1 580 Interaction with MYB (By similarity).
 REGION 1154 1344 Required for nuclear and nucleolar
 MOTIF 238 256 Nuclear export signal 1 (By similarity).
 MOTIF 261 279 Nuclear export signal 2 (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 14 14 Phosphoserine (By similarity).
 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 156 156 N6-acetyllysine (By similarity).
 MOD_RES 721 721 Phosphoserine (By similarity).
 MOD_RES 1162 1162 Phosphoserine (By similarity).
 MOD_RES 1166 1166 Phosphoserine (By similarity).
 MOD_RES 1189 1189 Phosphoserine (By similarity).
 MOD_RES 1193 1193 Phosphothreonine (By similarity).
 MOD_RES 1200 1200 Phosphoserine (By similarity).
 MOD_RES 1221 1221 Phosphoserine (By similarity).
 MOD_RES 1246 1246 Phosphoserine (By similarity).
 MOD_RES 1255 1255 Phosphoserine (By similarity).
 MOD_RES 1280 1280 Phosphothreonine (By similarity).
 MOD_RES 1283 1283 Phosphoserine (By similarity).
 MOD_RES 1318 1318 Phosphoserine (By similarity).
 MOD_RES 1323 1323 Phosphoserine (By similarity).
 MOD_RES 1325 1325 Phosphoserine (By similarity).
 MOD_RES 1329 1329 Phosphoserine (By similarity).  
Keyword
 Acetylation; Activator; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1344 AA 
Protein Sequence
MAEMKSPTKA EPASPAEAPQ GDRRSLLEHS REFLDFFWDI AKPDQETRLR ATEKLLEYLR 60
TRPSDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS FEDIQLCDIL GQIQEKYNLQ 120
AMNKAMMRPT LFANLFGVLA LFQSGRLVKD KEALMKCVRL LKILSHHYNH LQGQPVKALV 180
DILSEVPESM FQEILPKVLK GDMKVILSSP KYLELFLLAR QRVPAELESL VGSVDLFSED 240
NIPSLVNILK VAANSVKKEQ KLPDVALNLL RLALQENKFE RFWKEVLEEG LLKKPSYTSS 300
YMCFRLLGAS LPLLSDEQLQ LVMRGDLIRH FGEHMVVSKS QNPLRFIPEI SAYVGTFLEG 360
CQDDPKRQFT VMVAFTAITN QGLPVMPTFW RVTRFLNTEA LQNYVTWLRD MFLQPDLDSL 420
VDFSTANQKR VQVASLNVPE RTVFRLRKWI IHRLVSLVDH LHLEKDEAVV EQIARFCLFH 480
AFFKTKKATP QIPETKQHFS FPLEDGNRGV IVSAFFSLLQ TLSVKFRQTP DLAENGKPWT 540
YRLVQLADML LKHNRNVANV TPLTAQQRQA WDQMMSTLKE LEAQSSETRA IAFQHLLLLV 600
GLHLFKSPAE SCDVLGDIQT CIKKSMEQNL RRSRSRAKAS QEPVWVEVMV EILLSLLAQP 660
SNLMRQVVRS VFGHVCSHLT PRGLQLILAV LNPETNEDEE DNVVVTDTDE KQLKHGEDAD 720
SDSEDSKNSE SDVDSEDGEE SEEEDRDKDV DPGFRQQLME VLQAGNALGG EEEEEEELGD 780
EAMMALDQNL ASLFAEQKMR IQARHEEKNK LQKEKQLRRD FQIRALDLIE VLVTKQPEHP 840
LILELLEPLL NIIQRSMRSR GSTKQEQDLL HKTARIFMHH LCRARHYCHE VEPGAEALHA 900
QVERLVQQAG NQADASVALY YFNASLYLLR VLKGNTTKRY QDGQKLEGAD IKSEPKDSEV 960
QTTSCLDLDF VTRVYSASLE SLLTKRNSPL TIPMFLDLFS RYPVICKNLL PIVVQHVAGS 1020
SRPRHQAQAC LLLQKALSAR ELRVCFEDPE WEQLISQVLG KTTQTLQTLG EAQSKGEHQR 1080
ELSILELLNT VFRIVNHEKL SVDLTAFLGM LQGKQQKLQQ NLQQGNHSSG SSRLYDLYWQ 1140
AMNLLGVQRP KSEKKNVKDI PSDSQSPIST KRKKKGFLPE TKKRKKLKSE GTTSEKKAAS 1200
QQDAVTEGAM PAATGKDQPP STGKKRRKRV KANTPSQVNG VTVAKSPAPN NPTLSPSTPP 1260
AKTPKVQKKK EKLSQVNGST PVSPVEPESK KHQKALSTKE VKRRSSQSAL PKKRARLSLV 1320
SRSPSLLQSG IRKRRVARRR VQTP 1344 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0042564; C:NLS-dependent protein nuclear import complex; ISS:UniProtKB.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0042149; P:cellular response to glucose starvation; IEA:Compara.
 GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
 GO:0071158; P:positive regulation of cell cycle arrest; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR007015; DNA_pol_V. 
Pfam
 PF04931; DNA_pol_phi 
SMART
  
PROSITE
  
PRINTS