CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021545
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sideroflexin-1 
Protein Synonyms/Alias
 Tricarboxylate carrier protein; TCC 
Gene Name
 SFXN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49EQLESARKIVHDYRQubiquitination[1]
72ENELWRAKYIYDSAFubiquitination[1, 2, 3, 4]
86FHPDTGEKMILIGRMubiquitination[1, 3]
202LMRQRELKVGIPVTDubiquitination[1, 3, 4, 5]
223GESANAAKQAITQVVubiquitination[1, 3, 4, 5]
305LEAELQAKIQESHPEubiquitination[3]
320LRRVYFNKGL*****ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Might be involved in the transport of a component required for iron utilization into or out of the mitochondria. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Ion transport; Iron; Iron transport; Membrane; Mitochondrion; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 322 AA 
Protein Sequence
MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI VHDYRQGIVP 60
PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN MTITGCMMTF YRTTPAVLFW 120
QWINQSFNAV VNYTNRSGDA PLTVNELGTA YVSATTGAVA TALGLNALTK HVSPLIGRFV 180
PFAAVAAANC INIPLMRQRE LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG 240
MAIPPFIMNT LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA 300
ELQAKIQESH PELRRVYFNK GL 322 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0006826; P:iron ion transport; IEA:Compara. 
Interpro
 IPR004686; Mtc. 
Pfam
 PF03820; Mtc 
SMART
  
PROSITE
  
PRINTS