CPLM-005228

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-005228

UniProt Accession

GRIA2_MOUSE; P23819; Q61604; Q61605; Q8BG69; Q8BXU3; Q9D6D3

Genbank Protein ID

X57498; L32204; L32189; L32190; L32192; L32194; L32196; L32198; L32200; L32202; L32203; L32201; L32199; L32197; L32195; L32193; L32191; L32372; L32189; L32190; L32191; L32192; L32193; L32194; L32195; L32196; L32197; L32198; L32199; L32200; L32201; L32202; L32203; L32204; AK014389; AK043490; AK044574; AK046861

Genbank Nucleotide ID

CAA40735.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37653.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; AAC37654.1; BAB29316.1; BAC31557.1; BAC31986.1; BAC32899.1

Protein Name

Glutamate receptor 2

Protein Synonyms/Alias

GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2

Gene Name

Gria2

Gene Synonyms/Alias

Glur2

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
888	AKRMKVAKNAQNINP	ubiquitination	[1]
908	SQNFATYKEGYNVYG	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).

Sequence Annotation

BINDING 471 471 Glutamate (By similarity).
BINDING 506 506 Glutamate (By similarity).
BINDING 726 726 Glutamate (By similarity).
MOD_RES 683 683 Phosphoserine; by PKC (By similarity).
MOD_RES 717 717 Phosphoserine; by PKG (By similarity).
MOD_RES 869 869 Phosphotyrosine.
MOD_RES 876 876 Phosphotyrosine.
MOD_RES 880 880 Phosphoserine.
LIPID 610 610 S-palmitoyl cysteine.
LIPID 836 836 S-palmitoyl cysteine.
CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).
CARBOHYD 370 370 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).
DISULFID 78 330 By similarity.
DISULFID 739 794 By similarity.

Keyword

Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; RNA editing; Signal; Synapse; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

883 AA

Protein Sequence

MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP 60
HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG 120
THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV 180
GNINNDKKDE TYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL 240
GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT ATIKYTSALT 300
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI 360
KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT 420
ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI 480
WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD 540
PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF 600
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL 660
SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK 720
YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLGNAVNLA VLKLNEQGLL 780
DKLKNKWWYD KGECGSGGGD SKTPVNLAVL KLSEQGVLDK LKNKWWYDKG ECGAKDSGSK 840
EKTSALSLSN VAGVFYILVG GLGLAMLVAL IEFCYKSRAE AKRMKVAKNA QNINPSSSQN 900
SQNFATYKEG YNVYGIESVK I 921

Gene Ontology

GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:MGI.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0043005; C:neuron projection; IDA:BHF-UCL.
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO:0008021; C:synaptic vesicle; IDA:MGI.
GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB.
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IDA:MGI.
GO:0015277; F:kainate selective glutamate receptor activity; ISS:UniProtKB.
GO:0007268; P:synaptic transmission; IDA:MGI.

Interpro

IPR001828; ANF_lig-bd_rcpt.
IPR019594; Glu_rcpt_Glu/Gly-bd.
IPR001320; Iontro_glu_rcpt.
IPR001508; NMDA_rcpt.

Pfam

PF01094; ANF_receptor
PF00060; Lig_chan
PF10613; Lig_chan-Glu_bd

SMART

SM00918; Lig_chan-Glu_bd
SM00079; PBPe

PROSITE

PRINTS

PR00177; NMDARECEPTOR.