| Tag | Content |
|---|
| CPLM ID | CPLM-013601 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysophospholipid acyltransferase 5 |
Protein Synonyms/Alias | LPLAT 5; 1-acylglycerophosphocholine O-acyltransferase; Lysophosphatidylcholine acyltransferase 3; Lyso-PC acyltransferase 3; Membrane-bound O-acyltransferase domain-containing protein 5; O-acyltransferase domain-containing protein 5 |
Gene Name | Lpcat3 |
Gene Synonyms/Alias | Grcc3f; Mboat5; Oact5 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 354 | RYIFKRLKFLGNKEL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). |
Sequence Annotation | MOTIF 484 487 Di-lysine motif.
ACT_SITE 428 428 Potential.
CARBOHYD 308 308 N-linked (GlcNAc...) (Potential). |
Keyword | Acyltransferase; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 487 AA |
Protein Sequence | MASTADGDVG ETLGQMRGLW PGVEDLSLNK LATSLGASEQ ALRLIFSIFL GYPLALFYRH 60
YLFYKDSYLI HLFHAFSGLS IAYFNFGHQF YHSLLCVVLQ FLILRLMGRT ITAVFTTLCF 120
QMAYLLAGYY YTATGDYDIK WTMPHCVLTL KLIGLSIDYY DGGKDRNSLS SEQQKYAILG 180
VPSLLEVAGF SYFYGAFLVG PQFSMNHYMK LVKGQLTDVP GKMPNSTIPA LKRLSLGLVY 240
LVGYTLLSPH ITEDYLLTED YDTRPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILSGL 300
GFNGFEENGT VKWDACANMK VWLFETTPRF TGTIASFNIN TNAWVARYIF KRLKFLGNKE 360
LSQGLSLLFL ALWHGLHSGY LICFQMEFLI VIVEKQATNL IRDSPALSSL ASITALQPFY 420
YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV YRSIYFLGHV FFLSLLFTLP YVYKAMVPRK 480
EKLKKRE 487 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IEA:EC. GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |