CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 MYH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
1179KREAEFQKMRRDLEEacetylation[1]
1330RQLEEEVKAKNALAHacetylation[1]
1380EVAQWRTKYETDAIQacetylation[1]
1457KKQRNFDKILAEWKQacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1941 AA 
Protein Sequence
MSGADSEMAV FGEAAPYLRK SEKERIEAQN RPFDAKTSVF VAEPKESFVK GTIQSREAGK 60
VTVKTEAGAT LTVKDDQVFP MNPPKFDKIE DMAMMTHLHE PAVLYNLKER YAAWMIYTYS 120
GLFCVTVNPY KWLPVYNPEV VTAYRGKKRQ EAPPHIFSIS DNAYQFMLTD RENQSILITG 180
ESGAGKTVNT KRVIQYFATI AVTGDKKKEE VTSGKMQGTL EDQIISANPL LEAFGNAKTV 240
RNDNSSRFGK FIRIHFGTTG KLASADIETY LLEKSRVTFQ LKAERSYHIF YQITSNKKPE 300
LIEMLLITTN PYDYPFVSQG EITVPSIDDQ EELMATDSAI DILGFTNEEK VSIYKLTGAV 360
MHYGNMKFKQ KQREEQAEPD GTEVADKAAY LQGLNSADLL KALCYPRVKV GNEFVTKGQT 420
VEQVTNAVGA LAKAMYEKMF LWMVTRINQQ LDTKQPRQYF IGVLDIAGFE IFDFNTLEQL 480
CINFTNEKLQ QFFNHHMFVL EQEEYKKEGI EWEFIDFGMD LAACIELIEK PMGIFSILEE 540
ECMFPKATDT SFKNKLYDQH LGKSANFQKP KVVKGKVEAH FSLIHYAGTV DYNITGWLEK 600
NKDPLNDTVV GLYQKSSLKT LAHLFSGTQT SESEASGGGA KKGGKKKGSS FQTVSALFRE 660
NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL RCNGVLEGIR ICRKGFPSRI 720
LYADFKQRYK VLNASAIPEG QFIDSKKASE KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL 780
EEMRDDKLAQ LITRTQAMCR GFLARVEYQK MVERREALFC IQYNIRAFMN VKHWPWMKLF 840
FKIKPLLKSA ETEKEMATMK EEFQKTKEEL AKSEAKRKEL EEKMVSLLKE KNDLQLQVQA 900
EAEGLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL EDECSELKKD 960
IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT KEKKALQEAH QQTLDDLQAE 1020
EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK LRMDLERAKR KLEGDLKLAQ ESIMDIENEK 1080
QQLDEKLKNL LPVLNIKSKI EDEQALGIQL QKKIKELQAR IEELEEEIEA ERASRAKAEK 1140
QRSDLSRELE EISERLEEAG GATSAQIELN KKREAEFQKM RRDLEEATLQ HEATAATLRK 1200
KHADSVAELG EQIDNLQRVK QKLEKEKSEM KMEIDDLASN METVSKAKGN LEKMCRTLED 1260
QVSELKSKEE EQQRMINDLT TQRGRLQTES GEFSRQLDEK EALVSQLSRG KQAFTQQIEE 1320
LKRQLEEEVK AKNALAHALQ SSRHDCDLLR EQYEEEQESK AELQRALSKA NSEVAQWRTK 1380
YETDAIQRTE ELEEAKKKLA QRLQAAEEHV EAVNAKCASL EKTKQRLQNE VEDLMLDVER 1440
TNAACAALDK KQRNFDKILA EWKQKYEETH AELESSQKEA RSLGTELFKM KNAYEESLDQ 1500
LETLKRENKN LQQEISDLTE QIAEGGKRIH ELEKIKKQVE QEKCELQAAL EEAEASLEHE 1560
EGKILRIQLE LNQVKSEIDR KIAEKDEEID QLKRNHIRVV ESMQSTLDAE IRSRNDAIRL 1620
KKKMEGDLNE MEIQLNHANR MAAEALRNYR NTQGILKDTQ LHLDDALRGQ EDLKEQLAMV 1680
ERRANLLQAE IEELRATLEQ TERSRKIAEQ ELLDASERVQ LLHTQNTSLI NTKKKLETDI 1740
SQIQGEMEDI IQEARNADEK AKKAITDAAM MAEELKKEQD TSAHLERMKK NMEQTVKDLQ 1800
LRLDEAEQLA LKGGKKQIQK LEARVRELEG EVESEQKRNA EAVKGLRKHE RRVKELTYQT 1860
EEDRKNILRL QDLVDKLQAK VKSYKRQAEE AEEQSNTNLS KFRKLQHELE EAEERADIAE 1920
SQVNKLRVKS REVHTKIISE E 1941 
Gene Ontology
 GO:0031672; C:A band; IEA:Compara.
 GO:0005826; C:actomyosin contractile ring; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0001778; P:plasma membrane repair; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.