| Tag | Content |
|---|
| CPLM ID | CPLM-015278 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CBP80/20-dependent translation initiation factor |
Protein Synonyms/Alias | |
Gene Name | Ctif |
Gene Synonyms/Alias | Gm672; Kiaa0427 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 205 | QRPPGGNKPQQHGDH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By similarity). |
Sequence Annotation | DOMAIN 378 579 MIF4G.
REGION 1 305 Interaction with NCBP1/CBP80 (By
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 18 18 Phosphoserine.
MOD_RES 299 299 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Phosphoprotein; Reference proteome; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 600 AA |
Protein Sequence | MENSSAASAS SEAGSSRSQE IEELERFIDS YVLEYQVQGL LTDKTEGDGE SQRTQSHISQ 60
WTADCREQLD GSCSFSRGRA PPQQNGNKDN SLDMLGTDIW AANTFDSFSG ATWDLQPEKL 120
DFTQFHRKVR HTPKQPLPHI DREGCGKGKL EDGDGISLND IEKVLPTWQG YHPMPHEAEI 180
AHTKKLFRRR RNDRRRQQRP PGGNKPQQHG DHQPGSAKHN RDHQKSYQGG SGPHPSGRPT 240
HHGYSQNRRW HHGNMKHPPG DKGEAGSHRN AKETVTVENP KLEDGPGDTG HSGLEPPCSP 300
DTLTPAASER PTPQLPGGPE AEIKHKDTVL PERLRERPKI TLLQSSKDRL RRRLKEKDRD 360
IPNPTETSAP LRCVLCVPHV PQDEVAVETS SPQPSKMDRL MEILNIMRNN SSDVDAKLTS 420
FMEEAQNSTN SEEMLGEIVR TIYQKAVSDR SFAFTAAKLC DKMALFMVEG TKFRSLLLNM 480
LQKDFTVREE LQQQDVERWL GFITFLCEVF GTMRSSTGEP FRVLVCPIYT CLRELLQSQD 540
VKEDAVLCCS MELQSTGRLL EEQLPEMMTE LLASARDKML CPSESMLTRS LLLEVIELHA 600
NSWNPLTPPI TQYYNRTIQK LTA 623 |
Gene Ontology | GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0003723; F:RNA binding; IEA:InterPro. GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB. GO:0006446; P:regulation of translational initiation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |