UniProt Accession

 IPYR2_HUMAN; Q9H2U2; B4DLP7; F8WDN9; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9NX37; Q9P033; Q9ULX0 

Genbank Protein ID

 AB026722; AF217187; AK000466; AK297096; AC004066; AC106888; BC022803; BC039462; BC057219; AF161473; AL136655 

Genbank Nucleotide ID

 BAA84701.1; AAG36781.1; BAA91184.1; BAG59609.1; AAY41040.1; AAH22803.1; AAH39462.2; AAH57219.1; AAF29088.1; CAB66590.2 

Protein Name

 Inorganic pyrophosphatase 2, mitochondrial 

Protein Synonyms/Alias

 Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2 

Gene Name

 PPA2 

Gene Synonyms/Alias

 HSPC124 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	QNYRLFFKNVTGHYI	acetylation	[1]
73	IPLKVNSKEENGIPM	acetylation	[2]
81	EENGIPMKKARNDEY	acetylation	[2]
216	ANDPEASKFHDIDDV	acetylation	[1]
261	FNGEFKNKAFALEVI	acetylation	[1]
276	KSTHQCWKALLMKKC	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 METAL 164 164 Magnesium 1 (By similarity).
 METAL 169 169 Magnesium 1 (By similarity).
 METAL 169 169 Magnesium 2 (By similarity).
 METAL 201 201 Magnesium 1 (By similarity).
 MOD_RES 261 261 N6-acetyllysine.
 MOD_RES 317 317 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004427; F:inorganic diphosphatase activity; TAS:Reactome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0071344; P:diphosphate metabolic process; TAS:Reactome.
 GO:0006796; P:phosphate-containing compound metabolic process; IEA:InterPro.
 GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome. 

Interpro

 IPR008162; Pyrophosphatase. 

Pfam

 PF00719; Pyrophosphatase 

SMART

  

PROSITE

 PS00387; PPASE 

PRINTS