CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019883
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related GTP-binding protein C 
Protein Synonyms/Alias
 Rag C; RagC; GTPase-interacting protein 2; TIB929 
Gene Name
 Rragc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
78SGKSSIQKVVFHKMSubiquitination[1]
328NTTVLYLKEVTKFLAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity). 
Sequence Annotation
 NP_BIND 67 74 GTP (By similarity).
 NP_BIND 115 119 GTP (By similarity).
 NP_BIND 177 180 GTP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; GTP-binding; Lysosome; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 398 AA 
Protein Sequence
MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAG GGGGAGAGGG CGPGGADSSK 60
PRILLMGLRR SGKSSIQKVV FHKMSPNETL FLESTNKIYK DDISNSSFVN FQIWDFPGQM 120
DFFDPTFDYE MIFRGTGALI YVIDAQDDYM EALTRLHITV SKAYKVNPDM NFEVFIHKVD 180
GLSDDHKIET QRDIHQRAND DLADAGLEKL HLSFYLTSIY DHSIFEAFSK VVQKLIPQLP 240
TLENLLNIFI SNSGIEKAFL FDVVSKIYIA TDSSPVDMQS YELCCDMIDV VIDVSCIYGL 300
KEDGSGSAYD KESMAIIKLN NTTVLYLKEV TKFLALVCIL REESFERKGL IDYNFHCFRK 360
AIHEVFEVGV TSHRSCSHQT SAPSLKALAH NGTPRNAI 398 
Gene Ontology
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:HGNC.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:HGNC.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB. 
Interpro
 IPR006762; Gtr1_RagA.
 IPR027417; P-loop_NTPase. 
Pfam
 PF04670; Gtr1_RagA 
SMART
  
PROSITE
  
PRINTS