CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amyloid-like protein 2 
Protein Synonyms/Alias
 APLP-2; CDEI box-binding protein; CDEBP 
Gene Name
 Aplp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
688PEERHLNKMQNHGYEubiquitination[1]
700GYENPTYKYLEQMQIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide- catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. 
Sequence Annotation
 REGION 693 707 Interaction with DAB2.
 MOTIF 694 699 NPXY motif.
 CARBOHYD 485 485 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; DNA-binding; Glycoprotein; Membrane; Nucleus; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN 60
MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI TNVMEANQPV NIDSWCRRDK 120
RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ FFHQERMEVC EKHQRWHTLV KEACLTEGLT 180
LYSYGMLLPC GVDQFHGTEY VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF 240
PTEADLEDFT EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK 300
EIVHDVKVPP TPLPTNDVDV YFETSADDNE HARFQKAKEQ LEIRHRNRMD RVKKEWEEAE 360
LQAKNLPKTE RQTLIQHFQA MVKALEKEAA SEKQQLVETH LARVEAMLND RRRIALENYL 420
AALQSDPPRP HRILQALRRY VRAENKDRLH TIRHYQHVLA VDPEKAAQMK SQVMTHLHVI 480
EERRNQSLSL LYKVPYVAQE IQEEIDELLQ EQRADMDQFT SSISENPVDV RVSSEESEEI 540
PPFHPLHPFP SLSENEDTQP ELYHPMKKGS GMAEQDGGLI GAEEKVINSK NKMDENMVID 600
ETLDVKEMIF NAERVGGLEE EPESVGPLRE DFSLSSNALI GLLVIAVAIA TVIVISLVML 660
RKRQYGTISH GIVEVDPMLT PEERHLNKMQ NHGYENPTYK YLEQMQI 707 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IEA:InterPro.
 GO:0046914; F:transition metal ion binding; IEA:InterPro.
 GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
 GO:0008203; P:cholesterol metabolic process; IGI:MGI.
 GO:0009790; P:embryo development; IGI:MGI.
 GO:0030198; P:extracellular matrix organization; IGI:MGI.
 GO:0030900; P:forebrain development; IGI:MGI.
 GO:0007626; P:locomotory behavior; IGI:MGI.
 GO:0007617; P:mating behavior; IGI:MGI.
 GO:0030901; P:midbrain development; IGI:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
 GO:0007176; P:regulation of epidermal growth factor-activated receptor activity; IGI:MGI.
 GO:0043393; P:regulation of protein binding; IGI:MGI.
 GO:0001967; P:suckling behavior; IGI:MGI. 
Interpro
 IPR008155; Amyloid_glyco.
 IPR011178; Amyloid_glyco_Cu-bd.
 IPR024329; Amyloid_glyco_E2_domain.
 IPR008154; Amyloid_glyco_extra.
 IPR019744; Amyloid_glyco_extracell_CS.
 IPR015849; Amyloid_glyco_heparin-bd.
 IPR019745; Amyloid_glyco_intracell_CS.
 IPR019543; APP_amyloid_C. 
Pfam
 PF10515; APP_amyloid
 PF12924; APP_Cu_bd
 PF12925; APP_E2
 PF02177; APP_N 
SMART
 SM00006; A4_EXTRA 
PROSITE
 PS00319; A4_EXTRA
 PS00320; A4_INTRA 
PRINTS
 PR00203; AMYLOIDA4.