| Tag | Content |
|---|
| CPLM ID | CPLM-013974 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance-associated protein 7 |
Protein Synonyms/Alias | ATP-binding cassette sub-family C member 10 |
Gene Name | ABCC10 |
Gene Synonyms/Alias | MRP7; SIMRP7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 814 | QSVQNPEKTKEGLEE | ubiquitination | [1] | | 816 | VQNPEKTKEGLEEEQ | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. |
Sequence Annotation | DOMAIN 285 563 ABC transmembrane type-1 1.
DOMAIN 598 824 ABC transporter 1.
DOMAIN 885 1210 ABC transmembrane type-1 2.
DOMAIN 1246 1479 ABC transporter 2.
NP_BIND 633 640 ATP 1 (Potential).
NP_BIND 1280 1287 ATP 2 (Potential).
MOD_RES 463 463 Phosphothreonine.
MOD_RES 467 467 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1492 AA |
Protein Sequence | MCLLVFPLVP RSPDYILPCS PGWRLRLAAS FLLSVFPLLD LLPVALPPGA GPGPIGLEVL 60
AGCVAAVAWI SHSLALWVLA HSPHGHSRGP LALALVALLP APALVLTVLW HCQRGTLLPP 120
LLPGPMARLC LLILQLAALL AYALGWAAPG GPREPWAQEP LLPEDQEPEV AEDGESWLSR 180
FSYAWLAPLL ARGACGELRQ PQDICRLPHR LQPTYLARVF QAHWQEGARL WRALYGAFGR 240
CYLALGLLKL VGTMLGFSGP LLLSLLVGFL EEGQEPLSHG LLYALGLAGG AVLGAVLQNQ 300
YGYEVYKVTL QARGAVLNIL YCKALQLGPS RPPTGEALNL LGTDSERLLN FAGSFHEAWG 360
LPLQLAITLY LLYQQVGVAF VGGLILALLL VPVNKVIATR IMASNQEMLQ HKDARVKLVT 420
ELLSGIRVIK FCGWEQALGA RVEACRAREL GRLRVIKYLD AACVYLWAAL PVVISIVIFI 480
TYVLMGHQLT ATKVFTALAL VRMLILPLNN FPWVINGLLE AKVSLDRIQL FLDLPNHNPQ 540
AYYSPDCGRL GAQIKWLLCS DPPAEPSTVL ELHGALFSWD PVGTSLETFI SHLEVKKGML 600
VGIVGKVGCG KSSLLAAIAG ELHRLRGHVA VRGLSKGFGL ATQEPWIQFA TIRDNILFGK 660
TFDAQLYKEV LEACALNDDL SILPAGDQTE VGEKGVTLSG GQRARIALAR AVYQEKELYL 720
LDDPLAAVDA DVANHLLHRC ILGMLSYTTR LLCTHRTEYL ERADAVLLME AGRLIRAGPP 780
SEILPLVQAV PKAWAENGQE SDSATAQSVQ NPEKTKEGLE EEQSTSGRLL QEESKKEGAV 840
ALHVYQAYWK AVGQGLALAI LFSLLLMQAT RNAADWWLSH WISQLKAENS SQEAQPSTSP 900
ASMGLFSPQL LLFSPGNLYI PVFPLPKAAP NGSSDIRFYL TVYATIAGVN SLCTLLRAVL 960
FAAGTLQAAA TLHRRLLHRV LMAPVTFFNA TPTGRILNRF SSDVACADDS LPFILNILLA 1020
NAAGLLGLLA VLGSGLPWLL LLLPPLSIMY YHVQRHYRAS SRELRRLGSL TLSPLYSHLA 1080
DTLAGLSVLR ATGATYRFEE ENLRLLELNQ RCQFATSATM QWLDIRLQLM GAAVVSAIAG 1140
IALVQHQQGL ANPGLVGLSL SYALSLTGLL SGLVSSFTQT EAMLVSVERL EEYTCDLPQE 1200
PQGQPLQLGT GWLTQGGVEF QDVVLAYRPG LPNALDGVTF CVQPGEKLGI VGRTGSGKSS 1260
LLLVLFRLLE PSSGRVLLDG VDTSQLELAQ LRSQLAIIPQ EPFLFSGTVR ENLDPQGLHK 1320
DRALWQALKQ CHLSEVITSM GGLDGELGEG GRSLSLGQRQ LLCLARALLT DAKILCIDEA 1380
TASVDQKTDQ LLQQTICKRF ANKTVLTIAH RLNTILNSDR VLVLQAGRVV ELDSPATLRN 1440
QPHSLFQQLL QSSQQGVPAS LGGP 1464 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0055085; P:transmembrane transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |