CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023297
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cystine/glutamate transporter 
Protein Synonyms/Alias
 Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT 
Gene Name
 SLC7A11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MVRKPVVSTISubiquitination[1, 2, 3]
12PVVSTISKGGYLQGNubiquitination[1, 2, 3, 4, 5]
30RLPSLGNKEPPGQEKubiquitination[1, 2, 3]
37KEPPGQEKVQLKRKVubiquitination[1, 3]
222KGQTQNFKDAFSGRDubiquitination[1, 2, 3, 6]
483WFRIMSEKITRTLQIubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. 
Sequence Annotation
 MOD_RES 26 26 Phosphoserine.
 CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).  
Keyword
 Amino-acid transport; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA 60
GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP 120
LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN 180
SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY 240
YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS 300
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 360
RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP 420
FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM 480
SEKITRTLQI ILEVVPEEDK L 501 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0015327; F:cystine:glutamate antiporter activity; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0070306; P:lens fiber cell differentiation; IEA:Compara.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0070527; P:platelet aggregation; IEA:Compara.
 GO:0035094; P:response to nicotine; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0009636; P:response to toxic substance; IDA:UniProtKB. 
Interpro
 IPR002293; AA/rel_permease1.
 IPR004760; L_AA_transporter. 
Pfam
  
SMART
  
PROSITE
  
PRINTS