CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015640
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane and ubiquitin-like domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 TMUB2 
Gene Synonyms/Alias
 FP2653; UNQ1897/PRO4343 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145LDIQGLPKRQAGAGSubiquitination[1, 2, 3]
179GLITVRLKFLNDTEEubiquitination[1, 3]
200EDTVGALKSKYFPGQubiquitination[2]
202TVGALKSKYFPGQESubiquitination[4]
212PGQESQMKLIYQGRLubiquitination[1, 3, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
 DOMAIN 174 247 Ubiquitin-like.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 321 AA 
Protein Sequence
MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV LAWLSTYVAD 60
SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP HPSEGNDEKA EEAGEGRGDS 120
TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA GSSSPEAPLR SEDSTCLPPS PGLITVRLKF 180
LNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC 240
HRSPPGSAVP GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA 300
TVSLVGVTVF FSFLVFGMYG R 321 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF00240; ubiquitin 
SMART
 SM00213; UBQ 
PROSITE
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS