CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proprotein convertase subtilisin/kexin type 6 
Protein Synonyms/Alias
 Paired basic amino acid cleaving enzyme 4; Subtilisin-like proprotein convertase 4; SPC4; Subtilisin/kexin-like protease PACE4 
Gene Name
 PCSK6 
Gene Synonyms/Alias
 PACE4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136LRMDPQVKWLQQQEVubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. 
Sequence Annotation
 DOMAIN 496 634 Homo B/P.
 DOMAIN 931 969 PLAC.
 REGION 150 454 Catalytic.
 REGION 695 930 CRM (Cys-rich motif).
 MOTIF 553 555 Cell attachment site (Potential).
 ACT_SITE 205 205 Charge relay system (By similarity).
 ACT_SITE 246 246 Charge relay system (By similarity).
 ACT_SITE 420 420 Charge relay system (By similarity).
 CARBOHYD 259 259 N-linked (GlcNAc...) (Potential).
 CARBOHYD 914 914 N-linked (GlcNAc...) (Potential).
 CARBOHYD 932 932 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cleavage on pair of basic residues; Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 969 AA 
Protein Sequence
MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR WLLLLALPAA 60
CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI GNLEDYYHFY HSKTFKRSTL 120
SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ VRSDPQALYF NDPIWSNMWY LHCGDKNSRC 180
RSEMNVQAAW KRGYTGKNVV VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA 240
SNENKHGTRC AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID 300
IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR EGDYCSCDGY 360
TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE RKIVTTDLRQ RCTDGHTGTS 420
VSAPMVAGII ALALEANSQL TWRDVQHLLV KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL 480
VDAEALVVEA KKWTAVPSQH MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE 540
HVVVRTSISH PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG 600
QWTLEIQDLP SQVRNPEKQG KLKEWSLILY GTAEHPYHTF SAHQSRSRML ELSAPELEPP 660
KAALSPSQVE VPEDEEDYTA QSTPGSANIL QTSVCHPECG DKGCDGPNAD QCLNCVHFSL 720
GSVKTSRKCV SVCPLGYFGD TAARRCRRCH KGCETCSSRA ATQCLSCRRG FYHHQEMNTC 780
VTLCPAGFYA DESQKNCLKC HPSCKKCVDE PEKCTVCKEG FSLARGSCIP DCEPGTYFDS 840
ELIRCGECHH TCGTCVGPGR EECIHCAKNF HFHDWKCVPA CGEGFYPEEM PGLPHKVCRR 900
CDENCLSCAG SSRNCSRCKT GFTQLGTSCI TNHTCSNADE TFCEMVKSNR LCERKLFIQF 960
CCRTCLLAG 969 
Gene Ontology
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IDA:BHF-UCL.
 GO:0048406; F:nerve growth factor binding; IDA:BHF-UCL.
 GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0009100; P:glycoprotein metabolic process; IDA:BHF-UCL.
 GO:0032455; P:nerve growth factor processing; TAS:Reactome.
 GO:0032902; P:nerve growth factor production; IDA:BHF-UCL.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0030510; P:regulation of BMP signaling pathway; TAS:BHF-UCL.
 GO:0032940; P:secretion by cell; IDA:BHF-UCL.
 GO:0007354; P:zygotic determination of anterior/posterior axis, embryo; IEA:Compara. 
Interpro
 IPR006212; Furin_repeat.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR000209; Peptidase_S8/S53_dom.
 IPR023827; Peptidase_S8_Asp-AS.
 IPR022398; Peptidase_S8_His-AS.
 IPR023828; Peptidase_S8_Ser-AS.
 IPR015500; Peptidase_S8_subtilisin-rel.
 IPR010909; PLAC.
 IPR009020; Prot_inh_propept.
 IPR002884; PrprotnconvertsP. 
Pfam
 PF01483; P_proprotein
 PF00082; Peptidase_S8
 PF08686; PLAC 
SMART
 SM00261; FU 
PROSITE
 PS50900; PLAC
 PS00136; SUBTILASE_ASP
 PS00137; SUBTILASE_HIS
 PS00138; SUBTILASE_SER 
PRINTS
 PR00723; SUBTILISIN.