UniProt Accession

 CP17A_MOUSE; P27786 

Genbank Protein ID

 M64863 

Genbank Nucleotide ID

 AAA39877.1 

Protein Name

 Steroid 17-alpha-hydroxylase/17,20 lyase 

Protein Synonyms/Alias

 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17 

Gene Name

 Cyp17a1 

Gene Synonyms/Alias

 Cyp17 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
248	TLVEMFEKCKEKFNS	ubiquitination	[1]
252	MFEKCKEKFNSESLS	ubiquitination	[1]
329	EVKRKIQKEIDQYVG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. 

Sequence Annotation

 METAL 441 441 Iron (heme axial ligand) (By similarity).  

Keyword

 Complete proteome; Heme; Iron; Lyase; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome; Steroidogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004508; F:steroid 17-alpha-monooxygenase activity; IDA:MGI.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0018879; P:biphenyl metabolic process; IEA:Compara.
 GO:0071236; P:cellular response to antibiotic; IEA:Compara.
 GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IEA:Compara.
 GO:0006704; P:glucocorticoid biosynthetic process; IDA:MGI.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0042446; P:hormone biosynthetic process; ISS:UniProtKB.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0030728; P:ovulation; IEA:Compara.
 GO:0018958; P:phenol-containing compound metabolic process; IEA:Compara.
 GO:0018963; P:phthalate metabolic process; IEA:Compara.
 GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Compara.
 GO:0042448; P:progesterone metabolic process; ISS:UniProtKB.
 GO:0010034; P:response to acetate; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0060992; P:response to fungicide; IEA:Compara.
 GO:0009635; P:response to herbicide; IEA:Compara.
 GO:0017085; P:response to insecticide; IEA:Compara.
 GO:0010212; P:response to ionizing radiation; IEA:Compara.
 GO:0051597; P:response to methylmercury; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0048545; P:response to steroid hormone stimulus; IEA:Compara. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.