UniProt Accession

 RIB4_YEAST; P50861; D6W1S6; Q08286 

Genbank Protein ID

 Z21620; Z74885; AY558430; BK006948 

Genbank Nucleotide ID

 CAA79744.1; CAA99164.1; AAS56756.1; DAA10642.1 

Protein Name

 6,7-dimethyl-8-ribityllumazine synthase 

Protein Synonyms/Alias

 DMRL synthase; LS; Lumazine synthase 

Gene Name

 RIB4 

Gene Synonyms/Alias

 YOL143C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
17	DQVYDGSKIRVGIIH	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. 

Sequence Annotation

 REGION 61 63 5-amino-6-(D-ribitylamino)uracil binding.
 REGION 90 92 5-amino-6-(D-ribitylamino)uracil binding.
 REGION 95 96 1-deoxy-L-glycero-tetrulose 4-phosphate
 ACT_SITE 98 98 Proton donor (Potential).
 BINDING 27 27 5-amino-6-(D-ribitylamino)uracil.
 BINDING 123 123 5-amino-6-(D-ribitylamino)uracil; via
 BINDING 137 137 1-deoxy-L-glycero-tetrulose 4-phosphate.  

Keyword

 3D-structure; Complete proteome; Reference proteome; Riboflavin biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
 GO:0000906; F:6,7-dimethyl-8-ribityllumazine synthase activity; IGI:SGD.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0009231; P:riboflavin biosynthetic process; IMP:SGD. 

Interpro

 IPR002180; DMRL_synthase. 

Pfam

 PF00885; DMRL_synthase 

SMART

  

PROSITE

  

PRINTS