CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022534
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Teneurin-3 
Protein Synonyms/Alias
 Ten-3; Protein Odd Oz/ten-m homolog 3; Tenascin-M3; Ten-m3; Teneurin transmembrane protein 3 
Gene Name
 TENM3 
Gene Synonyms/Alias
 KIAA1455; ODZ3; TNM3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
835SPSQQAAKSFYDRISubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity). 
Sequence Annotation
 DOMAIN 1 309 Teneurin N-terminal.
 DOMAIN 514 545 EGF-like 1.
 DOMAIN 546 576 EGF-like 2.
 DOMAIN 578 610 EGF-like 3.
 DOMAIN 611 642 EGF-like 4.
 DOMAIN 644 677 EGF-like 5.
 DOMAIN 678 709 EGF-like 6.
 DOMAIN 710 739 EGF-like 7.
 DOMAIN 740 774 EGF-like 8.
 REPEAT 1200 1244 NHL 1.
 REPEAT 1270 1314 NHL 2.
 REPEAT 1331 1371 NHL 3.
 REPEAT 1402 1429 NHL 4.
 REPEAT 1458 1501 NHL 5.
 REPEAT 1511 1530 YD 1.
 REPEAT 1547 1567 YD 2.
 REPEAT 1610 1629 YD 3.
 REPEAT 1630 1652 YD 4.
 REPEAT 1823 1842 YD 5.
 REPEAT 1864 1882 YD 6.
 REPEAT 1883 1903 YD 7.
 REPEAT 1910 1927 YD 8.
 REPEAT 1928 1949 YD 9.
 REPEAT 1950 1967 YD 10.
 REPEAT 1970 1990 YD 11.
 REPEAT 1993 2013 YD 12.
 REPEAT 2021 2040 YD 13.
 REPEAT 2046 2063 YD 14.
 REPEAT 2064 2090 YD 15.
 REPEAT 2092 2105 YD 16.
 REPEAT 2106 2129 YD 17.
 REPEAT 2132 2152 YD 18.
 REPEAT 2153 2173 YD 19.
 REPEAT 2175 2195 YD 20.
 REPEAT 2207 2227 YD 21.
 REPEAT 2229 2249 YD 22.
 REPEAT 2275 2316 YD 23.
 CARBOHYD 345 345 N-linked (GlcNAc...) (Potential).
 CARBOHYD 380 380 N-linked (GlcNAc...) (Potential).
 CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
 CARBOHYD 670 670 N-linked (GlcNAc...) (Potential).
 CARBOHYD 860 860 N-linked (GlcNAc...) (Potential).
 CARBOHYD 883 883 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1202 1202 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1527 1527 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1544 1544 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1640 1640 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1677 1677 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1735 1735 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1820 1820 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1921 1921 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2124 2124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2264 2264 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2576 2576 N-linked (GlcNAc...) (Potential).
 DISULFID 518 528 By similarity.
 DISULFID 522 533 By similarity.
 DISULFID 535 544 By similarity.
 DISULFID 553 564 By similarity.
 DISULFID 566 575 By similarity.
 DISULFID 582 593 By similarity.
 DISULFID 587 598 By similarity.
 DISULFID 600 609 By similarity.
 DISULFID 614 625 By similarity.
 DISULFID 619 630 By similarity.
 DISULFID 632 641 By similarity.
 DISULFID 652 665 By similarity.
 DISULFID 667 676 By similarity.
 DISULFID 681 691 By similarity.
 DISULFID 685 696 By similarity.
 DISULFID 698 707 By similarity.
 DISULFID 712 722 By similarity.
 DISULFID 716 727 By similarity.
 DISULFID 729 738 By similarity.
 DISULFID 743 753 By similarity.
 DISULFID 747 762 By similarity.
 DISULFID 764 773 By similarity.  
Keyword
 Cell adhesion; Cell projection; Complete proteome; Differentiation; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Microphthalmia; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2699 AA 
Protein Sequence
MDVKERRPYC SLTKSRREKE RRYTNSSADN EECRVPTQKS YSSSETLKAF DHDSSRLLYG 60
NRVKDLVHRE ADEFTRQGQN FTLRQLGVCE PATRRGLAFC AEMGLPHRGY SISAGSDADT 120
ENEAVMSPEH AMRLWGRGVK SGRSSCLSSR SNSALTLTDT EHENKSDSEN EQPASNQGQS 180
TLQPLPPSHK QHSAQHHPSI TSLNRNSLTN RRNQSPAPPA ALPAELQTTP ESVQLQDSWV 240
LGSNVPLESR HFLFKTGTGT TPLFSTATPG YTMASGSVYS PPTRPLPRNT LSRSAFKFKK 300
SSKYCSWKCT ALCAVGVSVL LAILLSYFIA MHLFGLNWQL QQTENDTFEN GKVNSDTMPT 360
NTVSLPSGDN GKLGGFTQEN NTIDSGELDI GRRAIQEIPP GIFWRSQLFI DQPQFLKFNI 420
SLQKDALIGV YGRKGLPPSH TQYDFVELLD GSRLIAREQR SLLETERAGR QARSVSLHEA 480
GFIQYLDSGI WHLAFYNDGK NAEQVSFNTI VIESVVECPR NCHGNGECVS GTCHCFPGFL 540
GPDCSRAACP VLCSGNGQYS KGRCLCFSGW KGTECDVPTT QCIDPQCGGR GICIMGSCAC 600
NSGYKGESCE EADCIDPGCS NHGVCIHGEC HCSPGWGGSN CEILKTMCPD QCSGHGTYLQ 660
ESGSCTCDPN WTGPDCSNEI CSVDCGSHGV CMGGTCRCEE GWTGPACNQR ACHPRCAEHG 720
TCKDGKCECS QGWNGEHCTI EGCPGLCNSN GRCTLDQNGW HCVCQPGWRG AGCDVAMETL 780
CTDSKDNEGD GLIDCMDPDC CLQSSCQNQP YCRGLPDPQD IISQSLQSPS QQAAKSFYDR 840
ISFLIGSDST HVIPGESPFN KSLASVIRGQ VLTADGTPLI GVNVSFFHYP EYGYTITRQD 900
GMFDLVANGG ASLTLVFERS PFLTQYHTVW IPWNVFYVMD TLVMKKEEND IPSCDLSGFV 960
RPNPIIVSSP LSTFFRSSPE DSPIIPETQV LHEETTIPGT DLKLSYLSSR AAGYKSVLKI 1020
TMTQSIIPFN LMKVHLMVAV VGRLFQKWFP ASPNLAYTFI WDKTDAYNQK VYGLSEAVVS 1080
VGYEYESCLD LTLWEKRTAI LQGYELDASN MGGWTLDKHH VLDVQNGILY KGNGENQFIS 1140
QQPPVVSSIM GNGRRRSISC PSCNGQADGN KLLAPVALAC GIDGSLYVGD FNYVRRIFPS 1200
GNVTSVLELS SNPAHRYYLA TDPVTGDLYV SDTNTRRIYR PKSLTGAKDL TKNAEVVAGT 1260
GEQCLPFDEA RCGDGGKAVE ATLMSPKGMA VDKNGLIYFV DGTMIRKVDQ NGIISTLLGS 1320
NDLTSARPLT CDTSMHISQV RLEWPTDLAI NPMDNSIYVL DNNVVLQITE NRQVRIAAGR 1380
PMHCQVPGVE YPVGKHAVQT TLESATAIAV SYSGVLYITE TDEKKINRIR QVTTDGEISL 1440
VAGIPSECDC KNDANCDCYQ SGDGYAKDAK LSAPSSLAAS PDGTLYIADL GNIRIRAVSK 1500
NKPLLNSMNF YEVASPTDQE LYIFDINGTH QYTVSLVTGD YLYNFSYSND NDITAVTDSN 1560
GNTLRIRRDP NRMPVRVVSP DNQVIWLTIG TNGCLKSMTA QGLELVLFTY HGNSGLLATK 1620
SDETGWTTFF DYDSEGRLTN VTFPTGVVTN LHGDMDKAIT VDIESSSREE DVSITSNLSS 1680
IDSFYTMVQD QLRNSYQIGY DGSLRIIYAS GLDSHYQTEP HVLAGTANPT VAKRNMTLPG 1740
ENGQNLVEWR FRKEQAQGKV NVFGRKLRVN GRNLLSVDFD RTTKTEKIYD DHRKFLLRIA 1800
YDTSGHPTLW LPSSKLMAVN VTYSSTGQIA SIQRGTTSEK VDYDGQGRIV SRVFADGKTW 1860
SYTYLEKSMV LLLHSQRQYI FEYDMWDRLS AITMPSVARH TMQTIRSIGY YRNIYNPPES 1920
NASIITDYNE EGLLLQTAFL GTSRRVLFKY RRQTRLSEIL YDSTRVSFTY DETAGVLKTV 1980
NLQSDGFICT IRYRQIGPLI DRQIFRFSED GMVNARFDYS YDNSFRVTSM QGVINETPLP 2040
IDLYQFDDIS GKVEQFGKFG VIYYDINQII STAVMTYTKH FDAHGRIKEI QYEIFRSLMY 2100
WITIQYDNMG RVTKREIKIG PFANTTKYAY EYDVDGQLQT VYLNEKIMWR YNYDLNGNLH 2160
LLNPSNSARL TPLRYDLRDR ITRLGDVQYR LDEDGFLRQR GTEIFEYSSK GLLTRVYSKG 2220
SGWTVIYRYD GLGRRVSSKT SLGQHLQFFY ADLTYPTRIT HVYNHSSSEI TSLYYDLQGH 2280
LFAMEISSGD EFYIASDNTG TPLAVFSSNG LMLKQIQYTA YGEIYFDSNI DFQLVIGFHG 2340
GLYDPLTKLI HFGERDYDIL AGRWTTPDIE IWKRIGKDPA PFNLYMFRNN NPASKIHDVK 2400
DYITDVNSWL VTFGFHLHNA IPGFPVPKFD LTEPSYELVK SQQWDDIPPI FGVQQQVARQ 2460
AKAFLSLGKM AEVQVSRRRA GGAQSWLWFA TVKSLIGKGV MLAVSQGRVQ TNVLNIANED 2520
CIKVAAVLNN AFYLENLHFT IEGKDTHYFI KTTTPESDLG TLRLTSGRKA LENGINVTVS 2580
QSTTVVNGRT RRFADVEMQF GALALHVRYG MTLDEEKARI LEQARQRALA RAWAREQQRV 2640
RDGEEGARLW TEGEKRQLLS AGKVQGYDGY YVLSVEQYPE LADSANNIQF LRQSEIGRR 2699 
Gene Ontology
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; ISS:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; ISS:UniProtKB.
 GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR008969; CarboxyPept-like_regulatory.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR022385; Rhs_assc_core.
 IPR009471; Ten_N.
 IPR006530; YD. 
Pfam
 PF06484; Ten_N 
SMART
 SM00181; EGF 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS51125; NHL
 PS51361; TENEURIN_N 
PRINTS