| Tag | Content |
|---|
| CPLM ID | CPLM-015867 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 6 regulatory subunit 1 |
Protein Synonyms/Alias | SAPS domain family member 1 |
Gene Name | Ppp6r1 |
Gene Synonyms/Alias | Kiaa1115; Pp6r1; Saps1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 190 | FNWLNEEKIVQRLIE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha (By similarity). |
Sequence Annotation | REGION 10 403 Interaction with PPP6C (By similarity).
MOD_RES 524 524 Phosphothreonine (By similarity).
MOD_RES 529 529 Phosphoserine.
MOD_RES 530 530 Phosphoserine.
MOD_RES 531 531 Phosphoserine.
MOD_RES 633 633 Phosphoserine (By similarity).
MOD_RES 636 636 Phosphoserine (By similarity).
MOD_RES 698 698 Phosphoserine (By similarity).
MOD_RES 739 739 Phosphoserine (By similarity).
MOD_RES 826 826 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 856 AA |
Protein Sequence | MFWKFDLHTS SHLDTLLEKE DLSLPELLDE EDVLQECKVV NRKLLDFLLQ PSHLQAMVAW 60
VTQEPPASGE ERLRYKYPSV ACEILTSDVP QINDALGADE SLLNRLYGFL QSGDSLNPLL 120
ASFFSKVMGI LINRKTDQLV SFLRKKDDFV DLLLRHIGTS AIMDLLLRLL TCVERPQLRQ 180
DVFNWLNEEK IVQRLIEQIH PSKDDNQHSN ASQSLCDIIR LSREQMIQGQ DSPEPDQLLA 240
TLEKQETIEQ LLSNMFEGEQ CQSVIVSGIQ VLLTLLEPRR PRSDSVTMNN FFSSVDGQLE 300
LLAQGALDDA LSSMGALHAL RPRLDRFHQL LLEPPKLEPL QMTWGSLAPP LGNTRLHVVK 360
LLASALSANA AALTQELLVL DVPNTLLDLF FHYVFNNFLH AQVEVCVSAM LSSGPPPDSS 420
SETPVPNPIV KHLLQHCRLV ERILASWEEN DRVQSGGGPR KGYMGHLTRV ANAVVQNAEQ 480
GPNAEQLGQL LKELPEEQQQ RWEAFVSGPL AETNKKNTVD LVNTHHLHSS SDDEDDRLKE 540
FNFPEEAVLQ QAFMDFQMQR MTSAFIDHFG FNDEEFGEQE ESVNAPFDKT ANITFSLNAD 600
DENPNANLLE ICYKDRIQQF DDEEEEEEEG QGSAESDGEY GAWQGSQPVR ASQASQPPGV 660
RSGGSTDSEE EDEEEDEEED EGAEQAACGR TSPSSFPSPS TQPPGPSWTA TFDTVPMDAP 720
TGPPVSKEAD MSSIQIPSSP PAHGSPQLRS QDPTHPSAPQ EVTDSSKVAE PLAPCQALVS 780
VADVQATLHG MRSAPSSLDS ATRDPSTSVP DFKAHQSPQT MEGKRSPEHL GLPQSQSALE 840
MPNGSTPGGP ISSGSQ 856 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0019903; F:protein phosphatase binding; ISA:MGI. GO:0043666; P:regulation of phosphoprotein phosphatase activity; ISA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |